| pubmed-article:3136661 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3136661 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:3136661 | lifeskim:mentions | umls-concept:C0008328 | lld:lifeskim |
| pubmed-article:3136661 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:3136661 | lifeskim:mentions | umls-concept:C1996907 | lld:lifeskim |
| pubmed-article:3136661 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:3136661 | lifeskim:mentions | umls-concept:C0232572 | lld:lifeskim |
| pubmed-article:3136661 | pubmed:issue | 2 Pt 1 | lld:pubmed |
| pubmed-article:3136661 | pubmed:dateCreated | 1988-9-14 | lld:pubmed |
| pubmed-article:3136661 | pubmed:abstractText | The pathway by which cholecystokinin octapeptide (CCK-8) inhibits motility of the proximal stomach and the role of this pathway in the CCK-induced delay in gastric emptying of a liquid meal has been studied in rats by selective destruction of vagal afferent C-fibers using bilateral perineural application of the sensory neurotoxin, capsaicin, 3 or 4 days prior to the experiment. The capsaicin treatment significantly attenuated the decrease in intragastric pressure in urethan-anesthetized rats in response to CCK-8 (0.1-100 pmol iv) compared with vehicle-treated controls. Removal of the celiac-superior mesenteric ganglion completely abolished the inhibitory action of CCK-8 on gastric motility in these rats. In contrast, only celiac ganglionectomy in combination with vagotomy abolished the CCK-8 effect in vehicle-treated controls. Intravenous injection of CCK-8 (300 pmol) 5 min before intragastric administration of a methylcellulose solution decreased gastric emptying by 55% in conscious control or vehicle-treated rats. Perivagal capsaicin treatment abolished the delay in gastric emptying induced by CCK-8. In addition, capsaicin treatment alone significantly increased gastric emptying. These results demonstrate that CCK-8 decreases gastric motility in the gastric corpus and delays gastric emptying by a capsaicin-sensitive vagal afferent pathway. These same afferent fibers may also play a physiological role in the gastric emptying of liquids. | lld:pubmed |
| pubmed-article:3136661 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3136661 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3136661 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3136661 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3136661 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3136661 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:3136661 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:3136661 | pubmed:author | pubmed-author:TachéYY | lld:pubmed |
| pubmed-article:3136661 | pubmed:author | pubmed-author:RaybouldH EHE | lld:pubmed |
| pubmed-article:3136661 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3136661 | pubmed:volume | 255 | lld:pubmed |
| pubmed-article:3136661 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3136661 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3136661 | pubmed:pagination | G242-6 | lld:pubmed |
| pubmed-article:3136661 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:3136661 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3136661 | pubmed:articleTitle | Cholecystokinin inhibits gastric motility and emptying via a capsaicin-sensitive vagal pathway in rats. | lld:pubmed |
| pubmed-article:3136661 | pubmed:affiliation | Center for Ulcer Research and Education, Veterans Administration Wadsworth Medical Center, Los Angeles, California. | lld:pubmed |
| pubmed-article:3136661 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3136661 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3136661 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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