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pubmed-article:3134948pubmed:abstractTextApplication of laser irradiation with porphyrin(s) or their derivatives for the destruction of tumors in humans requires preliminary studies of their localization in normal and malignant tissues. A novel derivative of hematoporphyrin (HP) was prepared. The newly developed hematoporphyrin (DHP) was administered to Fisher rats with bladder tumors and showed greater accumulation in the tumoral tissues. Comparative data on (HP) and (DHP) are presented and discussed in light of the enhanced tumor porphyrin uptake caused by these agents. The homogeneous intense fluorescence noted with DHP-treated animals suggests that total tumor kill curative therapy will be more feasible. The study paves the way to refining increased porphyrin augment phototherapy and laser application in the field of oncology.lld:pubmed
pubmed-article:3134948pubmed:languageenglld:pubmed
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pubmed-article:3134948pubmed:statusMEDLINElld:pubmed
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pubmed-article:3134948pubmed:issn0300-9084lld:pubmed
pubmed-article:3134948pubmed:authorpubmed-author:GhoneimMMlld:pubmed
pubmed-article:3134948pubmed:authorpubmed-author:IbrahimEElld:pubmed
pubmed-article:3134948pubmed:authorpubmed-author:el-FarMMlld:pubmed
pubmed-article:3134948pubmed:authorpubmed-author:Abou-el-Zahab...lld:pubmed
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pubmed-article:3134948pubmed:volume70lld:pubmed
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pubmed-article:3134948pubmed:pagination251-8lld:pubmed
pubmed-article:3134948pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:3134948pubmed:year1988lld:pubmed
pubmed-article:3134948pubmed:articleTitleTumor localization of newly developed hematoporphyrin (DHP) using a bladder tumor model: a novel hematoporphyrin derivative.lld:pubmed
pubmed-article:3134948pubmed:affiliationFaculty of Science, Chemistry Dept., Mansoura University, Egypt.lld:pubmed
pubmed-article:3134948pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:3134948pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed