| pubmed-article:3133656 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3133656 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:3133656 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:3133656 | lifeskim:mentions | umls-concept:C0162493 | lld:lifeskim |
| pubmed-article:3133656 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:3133656 | lifeskim:mentions | umls-concept:C0019763 | lld:lifeskim |
| pubmed-article:3133656 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:3133656 | pubmed:dateCreated | 1988-8-10 | lld:pubmed |
| pubmed-article:3133656 | pubmed:abstractText | Stimulation of the human epithelial-like cell line, HeLa, with interferon gamma (IFN-gamma) induces steady-state levels of HLA-DR alpha mRNA. Using a sensitive RNase-mapping procedure, we detect induced HLA-DR alpha mRNA as early as 8 hr after IFN-gamma treatment; maximal accumulation occurs by 48 hr. Treatment with the protein synthesis inhibitor, cycloheximide, abolishes the IFN-gamma-induced accumulation of HLA-DR alpha mRNA, indicating that de novo synthesis of a trans-acting protein factor is required for induction of this major histocompatibility complex class II gene. Nuclear run-off transcription assays revealed that IFN-gamma acts by directly stimulating the transcription rate of HLA-DR alpha. Similarly, IFN-gamma increased the transcription rate of the class I HLA-A2-encoding gene as well as that of the human invariant chain gene. IFN-gamma-induced transcription of HLA-DR alpha and of the invariant chain gene was blocked by treatment with cycloheximide, but IFN-gamma-induced transcription of HLA-A2 was unaffected. Our findings show that transcriptional induction of HLA-DR alpha and the invariant chain gene by IFN-gamma requires the action of an unidentified trans-acting protein. | lld:pubmed |
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| pubmed-article:3133656 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3133656 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3133656 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3133656 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3133656 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:3133656 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:3133656 | pubmed:author | pubmed-author:FlavellR ARA | lld:pubmed |
| pubmed-article:3133656 | pubmed:author | pubmed-author:BlanarM AMA | lld:pubmed |
| pubmed-article:3133656 | pubmed:author | pubmed-author:BoettgerE CEC | lld:pubmed |
| pubmed-article:3133656 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3133656 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:3133656 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3133656 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3133656 | pubmed:pagination | 4672-6 | lld:pubmed |
| pubmed-article:3133656 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3133656 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3133656 | pubmed:articleTitle | Transcriptional activation of HLA-DR alpha by interferon gamma requires a trans-acting protein. | lld:pubmed |
| pubmed-article:3133656 | pubmed:affiliation | Biogen Research Corporation, Cambridge, MA 02142. | lld:pubmed |
| pubmed-article:3133656 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3133656 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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