| pubmed-article:3131869 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3131869 | lifeskim:mentions | umls-concept:C0026473 | lld:lifeskim |
| pubmed-article:3131869 | lifeskim:mentions | umls-concept:C0333516 | lld:lifeskim |
| pubmed-article:3131869 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:3131869 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:3131869 | pubmed:dateCreated | 1988-6-29 | lld:pubmed |
| pubmed-article:3131869 | pubmed:abstractText | The aim of this study was to examine the tumour necrosis factor (TNF)-alpha production by peripheral blood mononuclear cells activated by mitogens. Considerable amounts of TNF-alpha, ranging from 1.0 to 5.0 ng/ml, were present in the supernatants of cultures of human peripheral blood mononuclear cells (PBMC), stimulated with either the anti-CD3 monoclonal antibody OKT3 or the lectin phytohaemagglutinin (PHA). The amount of TNF-alpha secreted in the supernatant was closely correlated to the degree of T cell proliferation in such cultures, as measured by [3H]TdR incorporation. In the absence of proliferating T cells the mitogens did not induce secretion of TNF-alpha by monocytes. Supernatants of proliferating T cells were shown to induce TNF-alpha production by monocytes. The macrophage-activating factor gamma interferon (IFN-gamma) was also shown to induce, in the absence of endotoxin, TNF-alpha secretion by monocytes in a dose-dependent manner. The induction of TNF-alpha production by supernatants of proliferating T cells could largely be abrogated by passaging the supernatants on an anti-IFN-gamma column before adding them to the monocytes. It is therefore concluded from this study that the production of TNF-alpha by monocytes can be induced by proliferating T cells and that this induction can largely be attributed to the T cell lymphokine IFN-gamma. | lld:pubmed |
| pubmed-article:3131869 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3131869 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3131869 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3131869 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3131869 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3131869 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3131869 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3131869 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3131869 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3131869 | pubmed:month | May | lld:pubmed |
| pubmed-article:3131869 | pubmed:issn | 0300-9475 | lld:pubmed |
| pubmed-article:3131869 | pubmed:author | pubmed-author:BuurmanW AWA | lld:pubmed |
| pubmed-article:3131869 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:3131869 | pubmed:author | pubmed-author:DebetsJ MJM | lld:pubmed |
| pubmed-article:3131869 | pubmed:author | pubmed-author:SpronkenI EIE | lld:pubmed |
| pubmed-article:3131869 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3131869 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:3131869 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3131869 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3131869 | pubmed:pagination | 601-8 | lld:pubmed |
| pubmed-article:3131869 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:3131869 | pubmed:meshHeading | pubmed-meshheading:3131869-... | lld:pubmed |
| pubmed-article:3131869 | pubmed:meshHeading | pubmed-meshheading:3131869-... | lld:pubmed |
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| pubmed-article:3131869 | pubmed:meshHeading | pubmed-meshheading:3131869-... | lld:pubmed |
| pubmed-article:3131869 | pubmed:meshHeading | pubmed-meshheading:3131869-... | lld:pubmed |
| pubmed-article:3131869 | pubmed:meshHeading | pubmed-meshheading:3131869-... | lld:pubmed |
| pubmed-article:3131869 | pubmed:meshHeading | pubmed-meshheading:3131869-... | lld:pubmed |
| pubmed-article:3131869 | pubmed:meshHeading | pubmed-meshheading:3131869-... | lld:pubmed |
| pubmed-article:3131869 | pubmed:meshHeading | pubmed-meshheading:3131869-... | lld:pubmed |
| pubmed-article:3131869 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3131869 | pubmed:articleTitle | T cell-mediated production of tumour necrosis factor-alpha by monocytes. | lld:pubmed |
| pubmed-article:3131869 | pubmed:affiliation | Department of Surgery, University of Limburg, Maastricht, The Netherlands. | lld:pubmed |
| pubmed-article:3131869 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3131869 | pubmed:publicationType | In Vitro | lld:pubmed |
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