| pubmed-article:3125532 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3125532 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:3125532 | lifeskim:mentions | umls-concept:C0026030 | lld:lifeskim |
| pubmed-article:3125532 | lifeskim:mentions | umls-concept:C1882726 | lld:lifeskim |
| pubmed-article:3125532 | lifeskim:mentions | umls-concept:C1370121 | lld:lifeskim |
| pubmed-article:3125532 | lifeskim:mentions | umls-concept:C1880989 | lld:lifeskim |
| pubmed-article:3125532 | lifeskim:mentions | umls-concept:C0599473 | lld:lifeskim |
| pubmed-article:3125532 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:3125532 | pubmed:dateCreated | 1988-4-7 | lld:pubmed |
| pubmed-article:3125532 | pubmed:abstractText | Conjugation of racemic E-10-hydroxynortriptyline (E-10-OH-NT) with glucuronic acid was studied in the liver microsomal fraction of rats and humans. The diastereomeric glucuronides of E-10-OH-NT were resolved and quantitated by HPLC. Only the (+)-enantiomer was glucuronidated in liver microsomes from humans. Rat liver microsomes catalyzed the formation of both glucuronides. Phenobarbital pretreatment of rats increased the glucuronidation of both enantiomers about five-fold. The formation rate of (+)-E-10-OH-NT glucuronide varied from 5.5 to 33.2 pmol/mg x min, in microsomes from 13 humans. High activity was found in individuals previously treated with pentobarbital. Inhibition experiments with human liver microsomes showed that amitriptyline is a potent competitive inhibitor of (+)-E-10-OH-NT glucuronidation. p-Nitrophenol, paracetamol and 2-hydroxydesipramine also inhibited this reaction. | lld:pubmed |
| pubmed-article:3125532 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3125532 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3125532 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3125532 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3125532 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3125532 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3125532 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3125532 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3125532 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:3125532 | pubmed:issn | 0901-9928 | lld:pubmed |
| pubmed-article:3125532 | pubmed:author | pubmed-author:DumontEE | lld:pubmed |
| pubmed-article:3125532 | pubmed:author | pubmed-author:PerryT LTLJr | lld:pubmed |
| pubmed-article:3125532 | pubmed:author | pubmed-author:von BahrCC | lld:pubmed |
| pubmed-article:3125532 | pubmed:author | pubmed-author:BertilssonLL | lld:pubmed |
| pubmed-article:3125532 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3125532 | pubmed:volume | 61 | lld:pubmed |
| pubmed-article:3125532 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3125532 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3125532 | pubmed:pagination | 335-41 | lld:pubmed |
| pubmed-article:3125532 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3125532 | pubmed:meshHeading | pubmed-meshheading:3125532-... | lld:pubmed |
| pubmed-article:3125532 | pubmed:meshHeading | pubmed-meshheading:3125532-... | lld:pubmed |
| pubmed-article:3125532 | pubmed:meshHeading | pubmed-meshheading:3125532-... | lld:pubmed |
| pubmed-article:3125532 | pubmed:meshHeading | pubmed-meshheading:3125532-... | lld:pubmed |
| pubmed-article:3125532 | pubmed:meshHeading | pubmed-meshheading:3125532-... | lld:pubmed |
| pubmed-article:3125532 | pubmed:meshHeading | pubmed-meshheading:3125532-... | lld:pubmed |
| pubmed-article:3125532 | pubmed:meshHeading | pubmed-meshheading:3125532-... | lld:pubmed |
| pubmed-article:3125532 | pubmed:meshHeading | pubmed-meshheading:3125532-... | lld:pubmed |
| pubmed-article:3125532 | pubmed:meshHeading | pubmed-meshheading:3125532-... | lld:pubmed |
| pubmed-article:3125532 | pubmed:meshHeading | pubmed-meshheading:3125532-... | lld:pubmed |
| pubmed-article:3125532 | pubmed:meshHeading | pubmed-meshheading:3125532-... | lld:pubmed |
| pubmed-article:3125532 | pubmed:meshHeading | pubmed-meshheading:3125532-... | lld:pubmed |
| pubmed-article:3125532 | pubmed:meshHeading | pubmed-meshheading:3125532-... | lld:pubmed |
| pubmed-article:3125532 | pubmed:meshHeading | pubmed-meshheading:3125532-... | lld:pubmed |
| pubmed-article:3125532 | pubmed:meshHeading | pubmed-meshheading:3125532-... | lld:pubmed |
| pubmed-article:3125532 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3125532 | pubmed:articleTitle | Glucuronidation of the enantiomers of E-10-hydroxynortriptyline in human and rat liver microsomes. | lld:pubmed |
| pubmed-article:3125532 | pubmed:affiliation | Department of Clinical Pharmacology, Karolinska Institute, Huddinge University Hospital, Sweden. | lld:pubmed |
| pubmed-article:3125532 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3125532 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:3125532 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3125532 | lld:pubmed |
