| pubmed-article:3123331 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3123331 | lifeskim:mentions | umls-concept:C1261322 | lld:lifeskim |
| pubmed-article:3123331 | lifeskim:mentions | umls-concept:C0023775 | lld:lifeskim |
| pubmed-article:3123331 | lifeskim:mentions | umls-concept:C0851827 | lld:lifeskim |
| pubmed-article:3123331 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:3123331 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:3123331 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:3123331 | pubmed:dateCreated | 1988-2-26 | lld:pubmed |
| pubmed-article:3123331 | pubmed:abstractText | Chelation by citrate was found to promote the autoxidation of Fe2+, measured as the disappearance of 1,10-phenanthroline-chelatable Fe2+. The autoxidation of citrate-Fe2+ could in turn promote the peroxidation of microsomal phospholipid liposomes, as judged by malondialdehyde formation. At low citrate-Fe2+ ratios the autoxidation of Fe2+ was slow and the formation of malondialdehyde was preceded by a lag phase. The lag phase was eliminated by increasing the citrate-Fe2+ ratio, which also increased the rate of Fe2+ autoxidation. The Fe2+ autoxidation product required for the initiation of lipid peroxidation was characterized as being Fe3+. As direct evidence of this, linear initial rates of lipid peroxidation were obtained via the combination of citrate-Fe2+ and citrate-Fe3+, optimum activity occurring at a Fe3+-Fe2+ ratio of 1:1. Evidence is also presented to suggest that the superoxide and the hydrogen peroxide that are formed during the autoxidation of citrate-Fe2+ can either stimulate or inhibit lipid peroxidation by affecting the yield of citrate-Fe3+ from citrate-Fe2+. No evidence was obtained for the participation of the hydroxyl radical in the initiation of lipid peroxidation by citrate-Fe2+. | lld:pubmed |
| pubmed-article:3123331 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3123331 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3123331 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3123331 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3123331 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3123331 | pubmed:issn | 0891-5849 | lld:pubmed |
| pubmed-article:3123331 | pubmed:author | pubmed-author:AustS DSD | lld:pubmed |
| pubmed-article:3123331 | pubmed:author | pubmed-author:MinottiGG | lld:pubmed |
| pubmed-article:3123331 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3123331 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:3123331 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3123331 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3123331 | pubmed:pagination | 379-87 | lld:pubmed |
| pubmed-article:3123331 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:3123331 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3123331 | pubmed:articleTitle | An investigation into the mechanism of citrate-Fe2+-dependent lipid peroxidation. | lld:pubmed |
| pubmed-article:3123331 | pubmed:affiliation | Department of Biochemistry, Michigan State University, East Lansing 48824-1319. | lld:pubmed |
| pubmed-article:3123331 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3123331 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:3123331 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3123331 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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