| pubmed-article:3121132 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3121132 | lifeskim:mentions | umls-concept:C0014544 | lld:lifeskim |
| pubmed-article:3121132 | lifeskim:mentions | umls-concept:C0012010 | lld:lifeskim |
| pubmed-article:3121132 | lifeskim:mentions | umls-concept:C0446377 | lld:lifeskim |
| pubmed-article:3121132 | lifeskim:mentions | umls-concept:C2362312 | lld:lifeskim |
| pubmed-article:3121132 | lifeskim:mentions | umls-concept:C0003286 | lld:lifeskim |
| pubmed-article:3121132 | lifeskim:mentions | umls-concept:C0016293 | lld:lifeskim |
| pubmed-article:3121132 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:3121132 | lifeskim:mentions | umls-concept:C0360298 | lld:lifeskim |
| pubmed-article:3121132 | lifeskim:mentions | umls-concept:C0599946 | lld:lifeskim |
| pubmed-article:3121132 | lifeskim:mentions | umls-concept:C0700979 | lld:lifeskim |
| pubmed-article:3121132 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:3121132 | pubmed:dateCreated | 1988-2-12 | lld:pubmed |
| pubmed-article:3121132 | pubmed:abstractText | The ability of the imidazobenzodiazepine Ro 15-1788 to displace diazepam from brain membranes in vitro and to antagonize the anticonvulsant activity of diazepam in vivo was determined in epileptic fowl. At doses of 1.0 mg/kg and higher, Ro 15-1788 significantly attenuated the anticonvulsant action of diazepam (1.0 mg/kg) in epileptic chickens. Ro 15-1788 alone exerted no anticonvulsant activity even in doses as high as 10 mg/kg. Specific binding of 10 nM [3H]diazepam to whole homogenate fractions prepared from cerebral hemispheres of epileptic fowl was inhibited by Ro 15-1788 with an IC50 of 8.5 nM and the Ki was determined to be 4.25 nM. These results suggest that Ro 15-1788 competes directly with diazepam for a binding site involved in producing anticonvulsant activity. | lld:pubmed |
| pubmed-article:3121132 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3121132 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3121132 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3121132 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3121132 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3121132 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3121132 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:3121132 | pubmed:issn | 0006-8993 | lld:pubmed |
| pubmed-article:3121132 | pubmed:author | pubmed-author:JohnsonD DDD | lld:pubmed |
| pubmed-article:3121132 | pubmed:author | pubmed-author:CrawfordR DRD | lld:pubmed |
| pubmed-article:3121132 | pubmed:author | pubmed-author:TuchekJ MJM | lld:pubmed |
| pubmed-article:3121132 | pubmed:author | pubmed-author:WilcoxRR | lld:pubmed |
| pubmed-article:3121132 | pubmed:author | pubmed-author:PedderS CSC | lld:pubmed |
| pubmed-article:3121132 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3121132 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:3121132 | pubmed:volume | 424 | lld:pubmed |
| pubmed-article:3121132 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3121132 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3121132 | pubmed:pagination | 139-43 | lld:pubmed |
| pubmed-article:3121132 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3121132 | pubmed:meshHeading | pubmed-meshheading:3121132-... | lld:pubmed |
| pubmed-article:3121132 | pubmed:meshHeading | pubmed-meshheading:3121132-... | lld:pubmed |
| pubmed-article:3121132 | pubmed:meshHeading | pubmed-meshheading:3121132-... | lld:pubmed |
| pubmed-article:3121132 | pubmed:meshHeading | pubmed-meshheading:3121132-... | lld:pubmed |
| pubmed-article:3121132 | pubmed:meshHeading | pubmed-meshheading:3121132-... | lld:pubmed |
| pubmed-article:3121132 | pubmed:meshHeading | pubmed-meshheading:3121132-... | lld:pubmed |
| pubmed-article:3121132 | pubmed:meshHeading | pubmed-meshheading:3121132-... | lld:pubmed |
| pubmed-article:3121132 | pubmed:meshHeading | pubmed-meshheading:3121132-... | lld:pubmed |
| pubmed-article:3121132 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3121132 | pubmed:articleTitle | Benzodiazepine antagonist Ro 15-1788 (flumazepil) attenuates the anticonvulsant activity of diazepam in epileptic fowl. | lld:pubmed |
| pubmed-article:3121132 | pubmed:affiliation | Department of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, Canada. | lld:pubmed |
| pubmed-article:3121132 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3121132 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
