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pubmed-article:3116265pubmed:abstractTextWe isolated and sequenced six variable-region (V) gene segments of the human immunoglobulin heavy-chain (H) using the V71-2 segment as probe. These VH segments were more than 90% homologous to each other and less than 65% homologous to members of the three known VH families. The VH fragments hybridized to an identical set of restriction fragments on Southern blots of human placenta DNA. The new family was designated as the VH-IV family. The complexity of the VH-IV family was estimated to be at least nine genes, of which the sequenced seven were functional genes. The VH-IV family is homologous (76%) to the mouse Vh36-60 family.lld:pubmed
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pubmed-article:3116265pubmed:articleTitleA novel family of variable region genes of the human immunoglobulin heavy chain.lld:pubmed
pubmed-article:3116265pubmed:affiliationDepartment of Medical Chemistry, Kyoto University Faculty of Medicine, Japan.lld:pubmed
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