| pubmed-article:3114264 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3114264 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:3114264 | lifeskim:mentions | umls-concept:C0018557 | lld:lifeskim |
| pubmed-article:3114264 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:3114264 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:3114264 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:3114264 | lifeskim:mentions | umls-concept:C0022022 | lld:lifeskim |
| pubmed-article:3114264 | lifeskim:mentions | umls-concept:C1698986 | lld:lifeskim |
| pubmed-article:3114264 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:3114264 | lifeskim:mentions | umls-concept:C0061421 | lld:lifeskim |
| pubmed-article:3114264 | lifeskim:mentions | umls-concept:C0878412 | lld:lifeskim |
| pubmed-article:3114264 | lifeskim:mentions | umls-concept:C0333668 | lld:lifeskim |
| pubmed-article:3114264 | pubmed:issue | 26 | lld:pubmed |
| pubmed-article:3114264 | pubmed:dateCreated | 1987-10-21 | lld:pubmed |
| pubmed-article:3114264 | pubmed:abstractText | Animal cells respond to calcium ionophore (A23187) treatment with the coordinate induction of a set of genes encoding proteins identical to the glucose-regulated proteins (GRPs). By monitoring the intracellular free calcium with the fluorescent indicator fura-2 while employing both intracellular and extracellular calcium buffers, we demonstrated that A23187 can induce the GRP94 and GRP78 genes without an increase in cytoplasmic calcium ([Ca2+]i). Induction of GRP mRNA during glucose starvation was also independent of [Ca2+]i. Instead, gene induction by A23187 was closely correlated with the depletion of intracellular calcium stores. We conclude that perturbations of sequestered calcium ions by A23187 can serve as a stimulus for gene expression. | lld:pubmed |
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| pubmed-article:3114264 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:3114264 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3114264 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3114264 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:3114264 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:3114264 | pubmed:author | pubmed-author:LeaA OAO | lld:pubmed |
| pubmed-article:3114264 | pubmed:author | pubmed-author:SteinhardtR... | lld:pubmed |
| pubmed-article:3114264 | pubmed:author | pubmed-author:DrummondI AIA | lld:pubmed |
| pubmed-article:3114264 | pubmed:author | pubmed-author:ResendezEEJr | lld:pubmed |
| pubmed-article:3114264 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3114264 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:3114264 | pubmed:volume | 262 | lld:pubmed |
| pubmed-article:3114264 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3114264 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3114264 | pubmed:pagination | 12801-5 | lld:pubmed |
| pubmed-article:3114264 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:3114264 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3114264 | pubmed:articleTitle | Depletion of intracellular calcium stores by calcium ionophore A23187 induces the genes for glucose-regulated proteins in hamster fibroblasts. | lld:pubmed |
| pubmed-article:3114264 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3114264 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3114264 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:3114264 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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