| pubmed-article:3108383 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3108383 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:3108383 | lifeskim:mentions | umls-concept:C0376249 | lld:lifeskim |
| pubmed-article:3108383 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:3108383 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:3108383 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:3108383 | pubmed:dateCreated | 1987-7-15 | lld:pubmed |
| pubmed-article:3108383 | pubmed:abstractText | The reactivity of Lyt-2+ or L3T4+ T cells stimulated with either mutant class I or class II MHC alloantigens was studied. Whereas stimulation with class I MHC antigens induced only Lyt-2+ T cells to proliferate and to secrete IL 2, stimulation with class II MHC alloantigens induced L3T4+ but not Lyt-2+ T cells. When the frequencies of precursors of IL 2-secreting T lymphocytes (IL 2TL-p) were determined by limiting dilution analyses, class I MHC-reactive Lyt-2+ T cells displayed frequencies (f = 1/200) as high in magnitude as those within class II MHC-reactive L3T4+ (f = 1/100). Clonally developing IL 2TL of either T cell subset were antigen-specific, as shown in split-culture experiments. Whereas L3T4+ helper TL could be induced to specific IL 2 secretion over a long time period (days 3 to 9), Lyt-2+ TL showed a marked time optimal on day 4; thereafter, the number of TL colonies inducible to secrete IL 2 decreased steadily. IL 2 production and IL 2TL-p frequencies of unseparated T responder cells were not the numerical superposition of the two individual T cell subsets (Lyt-2+ + L3T4+); the latter finding is likely to reflect regulatory influences of Lyt-2+ T cells on IL 2-secreting L3T4+ T cells. | lld:pubmed |
| pubmed-article:3108383 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3108383 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3108383 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:3108383 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3108383 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3108383 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3108383 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3108383 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3108383 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3108383 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:3108383 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:3108383 | pubmed:author | pubmed-author:WagnerHH | lld:pubmed |
| pubmed-article:3108383 | pubmed:author | pubmed-author:SchmittJJ | lld:pubmed |
| pubmed-article:3108383 | pubmed:author | pubmed-author:SteenHH | lld:pubmed |
| pubmed-article:3108383 | pubmed:author | pubmed-author:KOCHF WFW | lld:pubmed |
| pubmed-article:3108383 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3108383 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:3108383 | pubmed:volume | 138 | lld:pubmed |
| pubmed-article:3108383 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3108383 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3108383 | pubmed:pagination | 4121-7 | lld:pubmed |
| pubmed-article:3108383 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3108383 | pubmed:meshHeading | pubmed-meshheading:3108383-... | lld:pubmed |
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| pubmed-article:3108383 | pubmed:meshHeading | pubmed-meshheading:3108383-... | lld:pubmed |
| pubmed-article:3108383 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3108383 | pubmed:articleTitle | Frequency analysis of class I MHC-reactive Lyt-2+ and class II MHC-reactive L3T4+ IL 2-secreting T lymphocytes. | lld:pubmed |
| pubmed-article:3108383 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3108383 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:3108383 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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