| pubmed-article:3106980 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3106980 | lifeskim:mentions | umls-concept:C0023434 | lld:lifeskim |
| pubmed-article:3106980 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:3106980 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:3106980 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:3106980 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:3106980 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:3106980 | pubmed:dateCreated | 1987-6-9 | lld:pubmed |
| pubmed-article:3106980 | pubmed:abstractText | Malignant B lymphocytes from several patients with chronic lymphocytic leukemia (CLL) were examined for reactivity with murine monoclonal antibody 17.109. This antibody, prepared against the rheumatoid factor (RF) paraprotein Sie, recognizes a crossreactive idiotype on 48% of human IgM RF paraproteins, but does not react with IgM paraproteins without RF activity or substantially with normal pooled immunoglobulin. The 17.109-reactive idiotype is a marker for a kappa III variable-region gene, designated V kappa RF, that is conserved in outbred human populations. In a limited study of 31 CLL patients, the leukemic cells from 5 of 20 patients with kappa light chain-expressing CLL were recognized by the 17.109 monoclonal antibody. Despite having malignant cells specifically reactive with this antibody, patients with 17.109-positive CLL did not have elevated serum levels of circulating antibody bearing 17.109-reactive determinants. Total RNAs isolated from the CLL B lymphocytes, or from hybridomas produced by fusing the CLL cells with the WI-L2-729-HF2 cell line, were fractionated electrophoretically and examined by blot hybridization. Under stringent hybridization conditions capable of discerning a single base-pair mismatch, RNA from the 17.109-idiotype-positive CLL cells hybridized to synthetic oligonucleotide probes corresponding to framework and complementary-determining regions in the V kappa RF gene. The high frequency of the 17.109-associated idiotype and the V kappa RF gene in CLL suggests that the disease may arise from B lymphocytes that express a restricted set of inherited immunoglobulin variable-region genes with little or no somatic mutation. | lld:pubmed |
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| pubmed-article:3106980 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:3106980 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3106980 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3106980 | pubmed:month | May | lld:pubmed |
| pubmed-article:3106980 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:3106980 | pubmed:author | pubmed-author:FongSS | lld:pubmed |
| pubmed-article:3106980 | pubmed:author | pubmed-author:KippsT JTJ | lld:pubmed |
| pubmed-article:3106980 | pubmed:author | pubmed-author:CarsonD ADA | lld:pubmed |
| pubmed-article:3106980 | pubmed:author | pubmed-author:GoldfienR DRD | lld:pubmed |
| pubmed-article:3106980 | pubmed:author | pubmed-author:TomhaveEE | lld:pubmed |
| pubmed-article:3106980 | pubmed:author | pubmed-author:ChenP PPP | lld:pubmed |
| pubmed-article:3106980 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3106980 | pubmed:volume | 84 | lld:pubmed |
| pubmed-article:3106980 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3106980 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3106980 | pubmed:pagination | 2916-20 | lld:pubmed |
| pubmed-article:3106980 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3106980 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3106980 | pubmed:articleTitle | High-frequency expression of a conserved kappa light-chain variable-region gene in chronic lymphocytic leukemia. | lld:pubmed |
| pubmed-article:3106980 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3106980 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3106980 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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