| pubmed-article:3106808 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3106808 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:3106808 | lifeskim:mentions | umls-concept:C1518069 | lld:lifeskim |
| pubmed-article:3106808 | lifeskim:mentions | umls-concept:C0205183 | lld:lifeskim |
| pubmed-article:3106808 | lifeskim:mentions | umls-concept:C1511695 | lld:lifeskim |
| pubmed-article:3106808 | lifeskim:mentions | umls-concept:C0205375 | lld:lifeskim |
| pubmed-article:3106808 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:3106808 | pubmed:dateCreated | 1987-5-27 | lld:pubmed |
| pubmed-article:3106808 | pubmed:abstractText | The term "benign lymphoepithelial lesion" is used to describe the salivary-gland lymphocytic infiltration and epithelial changes typically found in association with Sjögren's syndrome. We used Southern blot hybridization techniques to examine the immunoglobulin genes in salivary-gland tissue derived from eight patients with benign lymphoepithelial lesions. Three of these patients had intrasalivary non-Hodgkin's lymphoma complicating the lesions, whereas the lesions in the remaining five were all histologically benign. Ten samples from the eight patients all revealed rearrangement of both the heavy-chain and light-chain immunoglobulin genes. In one of the patients in whom non-Hodgkin's lymphoma involved both the salivary-gland lesion and an ipsilateral lymph node, the rearrangements of the heavy-chain and light-chain immunoglobulin genes detected at the two sites were identical. One other patient had two distinct benign lymphoepithelial lesions removed two years apart. The rearrangements of the heavy-chain as well as the kappa light-chain genes detected in these two lesions were entirely different. These data suggest that B-cell clonal expansion has an integral role in the pathophysiology of the benign lymphoepithelial lesion and may explain the increased incidence of lymphoma noted in association with this disorder. | lld:pubmed |
| pubmed-article:3106808 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3106808 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3106808 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:3106808 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3106808 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:3106808 | pubmed:issn | 0028-4793 | lld:pubmed |
| pubmed-article:3106808 | pubmed:author | pubmed-author:HesseBB | lld:pubmed |
| pubmed-article:3106808 | pubmed:author | pubmed-author:LevineHH | lld:pubmed |
| pubmed-article:3106808 | pubmed:author | pubmed-author:TubbsRR | lld:pubmed |
| pubmed-article:3106808 | pubmed:author | pubmed-author:FishlederAA | lld:pubmed |
| pubmed-article:3106808 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3106808 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:3106808 | pubmed:volume | 316 | lld:pubmed |
| pubmed-article:3106808 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3106808 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3106808 | pubmed:pagination | 1118-21 | lld:pubmed |
| pubmed-article:3106808 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
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| pubmed-article:3106808 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3106808 | pubmed:articleTitle | Uniform detection of immunoglobulin-gene rearrangement in benign lymphoepithelial lesions. | lld:pubmed |
| pubmed-article:3106808 | pubmed:publicationType | Journal Article | lld:pubmed |
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