| pubmed-article:3106474 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3106474 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:3106474 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:3106474 | lifeskim:mentions | umls-concept:C0017968 | lld:lifeskim |
| pubmed-article:3106474 | lifeskim:mentions | umls-concept:C0205360 | lld:lifeskim |
| pubmed-article:3106474 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:3106474 | lifeskim:mentions | umls-concept:C1706701 | lld:lifeskim |
| pubmed-article:3106474 | lifeskim:mentions | umls-concept:C0521115 | lld:lifeskim |
| pubmed-article:3106474 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:3106474 | pubmed:dateCreated | 1987-6-10 | lld:pubmed |
| pubmed-article:3106474 | pubmed:abstractText | The Pgp-1 glycoprotein was identified on a minor (27%) subset of peripheral Lyt-2+ or L3T4+ T cells. In contrast, mature medullary-type thymocytes (Lyt-2+ L3T4-, Lyt-2- L3T4+) were nearly devoid of cells expressing detectable surface Pgp-1. The appearance of peripheral Pgp-1- T cells was found to be thymus dependent, as demonstrated by the diminished proportion of Pgp-1- T cells after thymectomy and their virtual absence in athymic nude mice. The subsequent acquisition of surface Pgp-1 was found to be a stable differentiation event occurring concomitantly with primary antigenic stimulation; selected Pgp-1- mature T cells from thymus or periphery acquired constitutive expression of Pgp-1 after stimulation in vitro with alloantigen or mitogens. These observations were extended by studies in vivo showing that immunization with various antigens augmented the percentage of Pgp-1+ spleen cells within the Lyt-2+ subset. Furthermore, the frequencies of antigen-specific CTLp, after immunization by any of three different antigens tested, were greatly enriched in the Pgp-1+ compared with the Pgp-1- subpopulations. Peritoneal exudate Lyt-2+ cells, after a localized allograft rejection, demonstrated a particularly prominent Pgp-1+ subpopulation (78%) that contained virtually all the allospecific cytolytic activity. A model consistent with all of these data proposes that mature thymocytes lacking surface Pgp-1 upon emigration to the periphery acquire its expression at the time of primary antigenic stimulation. Hence, expression of Pgp-1 among peripheral T cells is an important differentiation marker for identifying antigen-stimulated memory T cells. | lld:pubmed |
| pubmed-article:3106474 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3106474 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3106474 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:3106474 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3106474 | pubmed:month | May | lld:pubmed |
| pubmed-article:3106474 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:3106474 | pubmed:author | pubmed-author:HorvathCC | lld:pubmed |
| pubmed-article:3106474 | pubmed:author | pubmed-author:MacDonaldH... | lld:pubmed |
| pubmed-article:3106474 | pubmed:author | pubmed-author:CerottiniJ... | lld:pubmed |
| pubmed-article:3106474 | pubmed:author | pubmed-author:BrosXX | lld:pubmed |
| pubmed-article:3106474 | pubmed:author | pubmed-author:HoweR CRC | lld:pubmed |
| pubmed-article:3106474 | pubmed:author | pubmed-author:BuddR CRC | lld:pubmed |
| pubmed-article:3106474 | pubmed:author | pubmed-author:PedrazziniTT | lld:pubmed |
| pubmed-article:3106474 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3106474 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:3106474 | pubmed:volume | 138 | lld:pubmed |
| pubmed-article:3106474 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3106474 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3106474 | pubmed:pagination | 3120-9 | lld:pubmed |
| pubmed-article:3106474 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:3106474 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3106474 | pubmed:articleTitle | Distinction of virgin and memory T lymphocytes. Stable acquisition of the Pgp-1 glycoprotein concomitant with antigenic stimulation. | lld:pubmed |
| pubmed-article:3106474 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3106474 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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