| pubmed-article:3105056 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3105056 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:3105056 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:3105056 | lifeskim:mentions | umls-concept:C0079004 | lld:lifeskim |
| pubmed-article:3105056 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:3105056 | lifeskim:mentions | umls-concept:C0035448 | lld:lifeskim |
| pubmed-article:3105056 | pubmed:issue | 4797 | lld:pubmed |
| pubmed-article:3105056 | pubmed:dateCreated | 1987-5-7 | lld:pubmed |
| pubmed-article:3105056 | pubmed:abstractText | B lymphocytes bearing the Leu-1 cell-surface antigen (Leu-1+), the human equivalent of mouse Ly-1+ B lymphocytes, have been detected in human peripheral blood, but there is little information on their frequency and properties. Analysis by fluorescence-activated cell sorter and double immunofluorescence showed that Leu-1+ B cells are consistently present in the peripheral blood and spleens of healthy subjects and constitute 17.0 +/- 5.0% (mean value +/- standard deviation) and 17.3 +/- 3.9%, respectively, of total B cells. When purified Leu-1+ and Leu-1- B lymphocytes were transformed into immunoglobulin-secreting cells by infection with Epstein-Barr virus and the culture fluids were tested for reactivity with self-antigens, at least two important autoantibodies, antibody to the Fc fragment of human immunoglobulin G (rheumatoid factor) and antibody to single-stranded DNA, were found to be made exclusively by Leu-1+ B cells. It is concluded that the Leu-1+ lymphocytes represent a major subset of the normal human B cell repertoire and include the B cells capable of making autoantibodies similar to those found in systemic lupus erythematosus and rheumatoid arthritis. | lld:pubmed |
| pubmed-article:3105056 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3105056 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3105056 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3105056 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3105056 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3105056 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:3105056 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:3105056 | pubmed:author | pubmed-author:NakamuraMM | lld:pubmed |
| pubmed-article:3105056 | pubmed:author | pubmed-author:CasalsJJ | lld:pubmed |
| pubmed-article:3105056 | pubmed:author | pubmed-author:NotkinsA LAL | lld:pubmed |
| pubmed-article:3105056 | pubmed:author | pubmed-author:InghiramiGG | lld:pubmed |
| pubmed-article:3105056 | pubmed:author | pubmed-author:BurasteroS... | lld:pubmed |
| pubmed-article:3105056 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3105056 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:3105056 | pubmed:volume | 236 | lld:pubmed |
| pubmed-article:3105056 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3105056 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3105056 | pubmed:pagination | 77-81 | lld:pubmed |
| pubmed-article:3105056 | pubmed:dateRevised | 2007-3-19 | lld:pubmed |
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| pubmed-article:3105056 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3105056 | pubmed:articleTitle | Human lymphocytes making rheumatoid factor and antibody to ssDNA belong to Leu-1+ B-cell subset. | lld:pubmed |
| pubmed-article:3105056 | pubmed:publicationType | Journal Article | lld:pubmed |
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