| pubmed-article:3102968 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3102968 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:3102968 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:3102968 | lifeskim:mentions | umls-concept:C1522642 | lld:lifeskim |
| pubmed-article:3102968 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:3102968 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:3102968 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:3102968 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:3102968 | lifeskim:mentions | umls-concept:C0376315 | lld:lifeskim |
| pubmed-article:3102968 | lifeskim:mentions | umls-concept:C0205296 | lld:lifeskim |
| pubmed-article:3102968 | pubmed:issue | 6106 | lld:pubmed |
| pubmed-article:3102968 | pubmed:dateCreated | 1987-4-1 | lld:pubmed |
| pubmed-article:3102968 | pubmed:abstractText | We have recently derived from human fetal blood (25 wks) a series of cloned cell lines that were selected for their ability to kill the conventional natural killer (NK) target cell K562. It was found that a fraction of these clones express CD3 proteins but not the monomorphic Ti alpha beta determinant recognized by WT31 antibody. One interleukin-2-dependent CD3+ WT31- clone, termed F6C7, was used for immunization of mice to generate monoclonal antibodies directed at a potentially novel recognition receptor. It was shown that F6C7 cells, which transcribe Ti beta but not Ti alpha genes, surface-express a clonotypic structure, termed NKFi. Immunoprecipitations performed with anti-NKFi monoclonal antibody (mAb) indicated that the corresponding molecule is resolved in SDS-polyacrylamide gel electrophoresis (PAGE) as a single band of relative molecular mass approximately 85,000 (Mr approximately 85K). After reduction, a major band was detected at 44K and a faint band was present at 41K. The present study was designed to characterize this structure. It was found that NKFi represents either two 44K disulphide-linked gamma (TCR) chains, or possibly one gamma chain associated to an additional undetected molecule, and that the 41K material corresponds to a partially glycosylated fraction of the gamma protein. Anti-NKFi mAb both induces a specific autocrine proliferative response and blocks cytotoxic function, demonstrating that gamma chains serve as functional receptor structures on subpopulations of normal human lymphocytes. | lld:pubmed |
| pubmed-article:3102968 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3102968 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3102968 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3102968 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3102968 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:3102968 | pubmed:author | pubmed-author:BohuonCC | lld:pubmed |
| pubmed-article:3102968 | pubmed:author | pubmed-author:FaureFF | lld:pubmed |
| pubmed-article:3102968 | pubmed:author | pubmed-author:ForestierFF | lld:pubmed |
| pubmed-article:3102968 | pubmed:author | pubmed-author:BellerFF | lld:pubmed |
| pubmed-article:3102968 | pubmed:author | pubmed-author:JitsukawaSS | lld:pubmed |
| pubmed-article:3102968 | pubmed:author | pubmed-author:TriebelFF | lld:pubmed |
| pubmed-article:3102968 | pubmed:author | pubmed-author:GrazianiMM | lld:pubmed |
| pubmed-article:3102968 | pubmed:author | pubmed-author:HercendTT | lld:pubmed |
| pubmed-article:3102968 | pubmed:author | pubmed-author:MoingeonPP | lld:pubmed |
| pubmed-article:3102968 | pubmed:author | pubmed-author:TroalenFF | lld:pubmed |
| pubmed-article:3102968 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3102968 | pubmed:volume | 325 | lld:pubmed |
| pubmed-article:3102968 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3102968 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3102968 | pubmed:pagination | 723-6 | lld:pubmed |
| pubmed-article:3102968 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:3102968 | pubmed:articleTitle | A gamma-chain complex forms a functional receptor on cloned human lymphocytes with natural killer-like activity. | lld:pubmed |
| pubmed-article:3102968 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3102968 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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