| pubmed-article:309900 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:309900 | lifeskim:mentions | umls-concept:C0521009 | lld:lifeskim |
| pubmed-article:309900 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:309900 | lifeskim:mentions | umls-concept:C0178539 | lld:lifeskim |
| pubmed-article:309900 | lifeskim:mentions | umls-concept:C2754997 | lld:lifeskim |
| pubmed-article:309900 | lifeskim:mentions | umls-concept:C0023810 | lld:lifeskim |
| pubmed-article:309900 | lifeskim:mentions | umls-concept:C0003261 | lld:lifeskim |
| pubmed-article:309900 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:309900 | lifeskim:mentions | umls-concept:C0301872 | lld:lifeskim |
| pubmed-article:309900 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:309900 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:309900 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:309900 | lifeskim:mentions | umls-concept:C1527178 | lld:lifeskim |
| pubmed-article:309900 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:309900 | pubmed:dateCreated | 1979-2-21 | lld:pubmed |
| pubmed-article:309900 | pubmed:abstractText | The role of thymus-derived lymphocytes (T cells) in LPS modulation of T cell-dependent antibody responses has been investigated. We have assessed the effect of LPS on the primary anti-TNP response to TNP-SRBC of cultures of whole spleen cells or T cell-depleted spleen cells that were supplemented with various subpopulations of carrier-primed (SRBC) spleen cells. The TNP-PFC response was enhanced in the presence of irradiated SRBC-primed spleen cells by addition of 0.16 to 20 microgram/ml LPS, but inhibition was observed when irradiation of primed cells was omitted. Enhancement but no inhibition occurred when added primed cells were first passed through a nylon wool column. LPS-mediated enhancement was dependent on a T cell in the primed population. These results suggest that LPS modulation of antibody synthesis is dependent on two populations of antigen-specific cells that have opposing effects on B cell responses to a T-dependent antigen: a helper cell that is irradiation resistant, nonadherent to nylon wool, and sensitive to anti-T cell serum, and a suppressor cell that is irradiation sensitive and adherent to nylon wool. | lld:pubmed |
| pubmed-article:309900 | pubmed:language | eng | lld:pubmed |
| pubmed-article:309900 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:309900 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:309900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:309900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:309900 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:309900 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:309900 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:309900 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:309900 | pubmed:author | pubmed-author:UchiyamaTT | lld:pubmed |
| pubmed-article:309900 | pubmed:author | pubmed-author:JacobsD MDM | lld:pubmed |
| pubmed-article:309900 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:309900 | pubmed:volume | 121 | lld:pubmed |
| pubmed-article:309900 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:309900 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:309900 | pubmed:pagination | 2347-51 | lld:pubmed |
| pubmed-article:309900 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:309900 | pubmed:meshHeading | pubmed-meshheading:309900-A... | lld:pubmed |
| pubmed-article:309900 | pubmed:meshHeading | pubmed-meshheading:309900-M... | lld:pubmed |
| pubmed-article:309900 | pubmed:meshHeading | pubmed-meshheading:309900-L... | lld:pubmed |
| pubmed-article:309900 | pubmed:meshHeading | pubmed-meshheading:309900-I... | lld:pubmed |
| pubmed-article:309900 | pubmed:meshHeading | pubmed-meshheading:309900-D... | lld:pubmed |
| pubmed-article:309900 | pubmed:meshHeading | pubmed-meshheading:309900-I... | lld:pubmed |
| pubmed-article:309900 | pubmed:meshHeading | pubmed-meshheading:309900-C... | lld:pubmed |
| pubmed-article:309900 | pubmed:meshHeading | pubmed-meshheading:309900-T... | lld:pubmed |
| pubmed-article:309900 | pubmed:meshHeading | pubmed-meshheading:309900-D... | lld:pubmed |
| pubmed-article:309900 | pubmed:year | 1978 | lld:pubmed |
| pubmed-article:309900 | pubmed:articleTitle | Modulation of immune response by bacterial lipopolysaccharide (LPS): cellular basis of stimulatory and inhibitory effects of LPS on the in vitro IgM antibody response to a T-dependent antigen. | lld:pubmed |
| pubmed-article:309900 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:309900 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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