| pubmed-article:3098783 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3098783 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:3098783 | lifeskim:mentions | umls-concept:C0521346 | lld:lifeskim |
| pubmed-article:3098783 | lifeskim:mentions | umls-concept:C0033809 | lld:lifeskim |
| pubmed-article:3098783 | lifeskim:mentions | umls-concept:C0008778 | lld:lifeskim |
| pubmed-article:3098783 | lifeskim:mentions | umls-concept:C0034211 | lld:lifeskim |
| pubmed-article:3098783 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:3098783 | lifeskim:mentions | umls-concept:C0044414 | lld:lifeskim |
| pubmed-article:3098783 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:3098783 | pubmed:dateCreated | 1987-1-29 | lld:pubmed |
| pubmed-article:3098783 | pubmed:abstractText | Pseudomonas aeruginosa culture filtrates varied in their ability to slow human ciliary beat frequency (7-71%). This activity did not correlate with known virulence factors. However, a close correlation (r = 0.97) existed between ciliary slowing and pigment content. In a prolonged culture, the increase in activity correlated (r = 0.94) with pigment accumulation. Gel filtration of lyophilized filtrate yielded a single peak of activity corresponding to the pigment fraction. Pyocyanin extracted from an active strain, and 1-hydroxyphenazine were purified by high performance liquid chromatography, and characterized by ultraviolet absorbance spectra and mass spectrometry. Both slowed cilia in a dose-dependent manner, and were synthesized and shown to be indistinguishable from the biological compounds. Pyocyanin caused gradual onset of slowing and ultimate widespread ciliostasis with epithelial disruption. 1-hydroxyphenazine caused rapid onset of ciliary slowing associated with dyskinesia and ciliostasis. Pyocyanin assayed within filtrates accounted for a significant proportion of the bioactivity present. | lld:pubmed |
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| pubmed-article:3098783 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3098783 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3098783 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:3098783 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3098783 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:3098783 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:3098783 | pubmed:author | pubmed-author:WilsonRR | lld:pubmed |
| pubmed-article:3098783 | pubmed:author | pubmed-author:ColePP | lld:pubmed |
| pubmed-article:3098783 | pubmed:author | pubmed-author:RobertsDD | lld:pubmed |
| pubmed-article:3098783 | pubmed:author | pubmed-author:TaylorGG | lld:pubmed |
| pubmed-article:3098783 | pubmed:author | pubmed-author:MacDermotJJ | lld:pubmed |
| pubmed-article:3098783 | pubmed:author | pubmed-author:WatsonDD | lld:pubmed |
| pubmed-article:3098783 | pubmed:author | pubmed-author:SykesDD | lld:pubmed |
| pubmed-article:3098783 | pubmed:author | pubmed-author:PitzRR | lld:pubmed |
| pubmed-article:3098783 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3098783 | pubmed:volume | 79 | lld:pubmed |
| pubmed-article:3098783 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3098783 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3098783 | pubmed:pagination | 221-9 | lld:pubmed |
| pubmed-article:3098783 | pubmed:dateRevised | 2010-9-9 | lld:pubmed |
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| pubmed-article:3098783 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3098783 | pubmed:articleTitle | Pyocyanin and 1-hydroxyphenazine produced by Pseudomonas aeruginosa inhibit the beating of human respiratory cilia in vitro. | lld:pubmed |
| pubmed-article:3098783 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3098783 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:3098783 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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