| pubmed-article:3090550 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3090550 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:3090550 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:3090550 | lifeskim:mentions | umls-concept:C0040114 | lld:lifeskim |
| pubmed-article:3090550 | lifeskim:mentions | umls-concept:C0034819 | lld:lifeskim |
| pubmed-article:3090550 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:3090550 | lifeskim:mentions | umls-concept:C0597360 | lld:lifeskim |
| pubmed-article:3090550 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:3090550 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:3090550 | pubmed:dateCreated | 1986-9-25 | lld:pubmed |
| pubmed-article:3090550 | pubmed:abstractText | The expression of interleukin 2 receptors (IL-2R) is a critical step leading to normal lymphocyte proliferation. Since thymosin fraction 5 (TF5), a thymic hormone preparation, enhances lymphoproliferative responses of human cells, we examined the effects of TF5 on the expression of IL-2R on mitogen-stimulated human lymphocytes. TF5 significantly increased the percentage and antigen density of cells expressing IL-2R after stimulation with an optimal concentration of phytohemagglutinin (PHA) when the cells from the same donor exhibited suboptimal responses to PHA alone. The same effect was observed with a suboptimal PHA concentration and with OKT3 monoclonal antibody stimulation. Thymosin alpha 1, a synthetic polypeptide originally isolated in its native form from TF5, was also able to increase IL-2R expression in response to PHA, suggesting that it is the active species in TF5. The enhancement of IL-2R expression was paralleled by increased proliferative responses. Increased IL-2R expression appears to be the direct effect of thymic hormones, since abrogation of interleukin 2 production by cyclosporin A did not affect TF5-mediated enhancement of PHA-induced IL-2R expression. These results point to a physiological role of thymic hormones in the maintenance of normal levels of IL-2R expression. This immunoregulatory activity of thymic hormones might be relevant in the treatment of conditions where there is decreased IL-2R expression, such as the acquired immune-deficiency syndrome, or in the restoration of normal IL-2R expression to lymphocytes from aged individuals. | lld:pubmed |
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| pubmed-article:3090550 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3090550 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3090550 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3090550 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3090550 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:3090550 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:3090550 | pubmed:author | pubmed-author:GoldsteinA... | lld:pubmed |
| pubmed-article:3090550 | pubmed:author | pubmed-author:SzteinM BMB | lld:pubmed |
| pubmed-article:3090550 | pubmed:author | pubmed-author:SerrateS ASA | lld:pubmed |
| pubmed-article:3090550 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3090550 | pubmed:volume | 83 | lld:pubmed |
| pubmed-article:3090550 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3090550 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3090550 | pubmed:pagination | 6107-11 | lld:pubmed |
| pubmed-article:3090550 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3090550 | pubmed:meshHeading | pubmed-meshheading:3090550-... | lld:pubmed |
| pubmed-article:3090550 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3090550 | pubmed:articleTitle | Modulation of interleukin 2 receptor expression on normal human lymphocytes by thymic hormones. | lld:pubmed |
| pubmed-article:3090550 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3090550 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3090550 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:3090550 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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