| pubmed-article:3088042 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3088042 | lifeskim:mentions | umls-concept:C0022660 | lld:lifeskim |
| pubmed-article:3088042 | lifeskim:mentions | umls-concept:C0004610 | lld:lifeskim |
| pubmed-article:3088042 | lifeskim:mentions | umls-concept:C0017436 | lld:lifeskim |
| pubmed-article:3088042 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:3088042 | lifeskim:mentions | umls-concept:C0599739 | lld:lifeskim |
| pubmed-article:3088042 | lifeskim:mentions | umls-concept:C1514118 | lld:lifeskim |
| pubmed-article:3088042 | lifeskim:mentions | umls-concept:C1517004 | lld:lifeskim |
| pubmed-article:3088042 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:3088042 | pubmed:dateCreated | 1986-8-6 | lld:pubmed |
| pubmed-article:3088042 | pubmed:abstractText | To explore whether bacteremia potentiates gentamicin nephrotoxicity, we injected rats with either 1 X 10(9) Escherichia coli (E. coli), Pseudomonas aeruginosa, or Staphylococcus aureus, and then gave them gentamicin, 100 mg/kg. Renal injury was assessed over the next 24-48 h. Staphylococcus/gentamicin or gentamicin alone induced no renal injury. However, E. coli/gentamicin and Pseudomonas/gentamicin caused acute renal failure (severe azotemia; tubular necrosis; cast formation). This effect was not due to acute reductions in arterial blood pressure or renal blood flow, it could be reproduced by substituting nonviable for viable gram-negative organisms, and it was associated with increased renal gentamicin uptake. E. coli without gentamicin induced only mild azotemia and no tubular necrosis. Endotoxin-tolerant rats were significantly protected against the E. coli/gentamicin nephrotoxic interaction. We conclude that gram-negative bacteremia and gentamicin exert synergistic nephrotoxicities; and that this effect is mediated, at least in part, by endotoxin and in part by increased renal gentamicin uptake. | lld:pubmed |
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| pubmed-article:3088042 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:3088042 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:3088042 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3088042 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:3088042 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:3088042 | pubmed:author | pubmed-author:PriorR BRB | lld:pubmed |
| pubmed-article:3088042 | pubmed:author | pubmed-author:ZagerR ARA | lld:pubmed |
| pubmed-article:3088042 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3088042 | pubmed:volume | 78 | lld:pubmed |
| pubmed-article:3088042 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3088042 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3088042 | pubmed:pagination | 196-204 | lld:pubmed |
| pubmed-article:3088042 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:3088042 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3088042 | pubmed:articleTitle | Gentamicin and gram-negative bacteremia. A synergism for the development of experimental nephrotoxic acute renal failure. | lld:pubmed |
| pubmed-article:3088042 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3088042 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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