| pubmed-article:3085095 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3085095 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:3085095 | lifeskim:mentions | umls-concept:C1334043 | lld:lifeskim |
| pubmed-article:3085095 | lifeskim:mentions | umls-concept:C2697616 | lld:lifeskim |
| pubmed-article:3085095 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:3085095 | pubmed:dateCreated | 1986-5-23 | lld:pubmed |
| pubmed-article:3085095 | pubmed:abstractText | A group of cytokines characterized by a common set of target cells--namely, the pluripotential hemopoietic stem cells or their cellular derivatives--share similarities in the amino acid sequence at their N terminus or in the putative signal peptide immediately prior to the published N terminus. Murine P-cell-stimulating factor (PSF), murine and human interleukin 2 (IL-2), murine and human granulocyte-macrophage colony-stimulating factor (GM-CSF), human erythropoietin, and human interleukin 1 beta all share alanine as the N-terminal amino acid and have some similarities in the succeeding three or four amino acids. In the case of murine PSF and GM-CSF, the six N-terminal amino acids are readily cleaved from mature molecules and are lacking from the N-terminal amino acid sequences reported initially. A sixth cytokine, colony-stimulating factor 1, has an alanine followed by a similar pattern of five amino acids at the end of the putative signal peptide. GM-CSF and IL-2 have more extensive homology, about 25% of residues being identical in three regions that comprise about 70% of the molecules. Only minor similarities of uncertain significance were found among the complete amino acid sequences of the other cytokines. Although its evolutionary origin is uncertain, the homology around the N terminus may provide a structural marker for a group of cytokines active on the pluripotential hemopoietic stem cell and its derivatives. | lld:pubmed |
| pubmed-article:3085095 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3085095 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3085095 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3085095 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3085095 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:3085095 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:3085095 | pubmed:author | pubmed-author:SchraderJ WJW | lld:pubmed |
| pubmed-article:3085095 | pubmed:author | pubmed-author:ZiltenerH JHJ | lld:pubmed |
| pubmed-article:3085095 | pubmed:author | pubmed-author:LeslieK BKB | lld:pubmed |
| pubmed-article:3085095 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3085095 | pubmed:volume | 83 | lld:pubmed |
| pubmed-article:3085095 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3085095 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3085095 | pubmed:pagination | 2458-62 | lld:pubmed |
| pubmed-article:3085095 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:3085095 | pubmed:meshHeading | pubmed-meshheading:3085095-... | lld:pubmed |
| pubmed-article:3085095 | pubmed:meshHeading | pubmed-meshheading:3085095-... | lld:pubmed |
| pubmed-article:3085095 | pubmed:meshHeading | pubmed-meshheading:3085095-... | lld:pubmed |
| pubmed-article:3085095 | pubmed:meshHeading | pubmed-meshheading:3085095-... | lld:pubmed |
| pubmed-article:3085095 | pubmed:meshHeading | pubmed-meshheading:3085095-... | lld:pubmed |
| pubmed-article:3085095 | pubmed:meshHeading | pubmed-meshheading:3085095-... | lld:pubmed |
| pubmed-article:3085095 | pubmed:meshHeading | pubmed-meshheading:3085095-... | lld:pubmed |
| pubmed-article:3085095 | pubmed:meshHeading | pubmed-meshheading:3085095-... | lld:pubmed |
| pubmed-article:3085095 | pubmed:meshHeading | pubmed-meshheading:3085095-... | lld:pubmed |
| pubmed-article:3085095 | pubmed:meshHeading | pubmed-meshheading:3085095-... | lld:pubmed |
| pubmed-article:3085095 | pubmed:meshHeading | pubmed-meshheading:3085095-... | lld:pubmed |
| pubmed-article:3085095 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3085095 | pubmed:articleTitle | Structural homologies among the hemopoietins. | lld:pubmed |
| pubmed-article:3085095 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3085095 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:3085095 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3085095 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3085095 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3085095 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3085095 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3085095 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3085095 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3085095 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3085095 | lld:pubmed |
