| pubmed-article:3084391 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3084391 | lifeskim:mentions | umls-concept:C1441547 | lld:lifeskim |
| pubmed-article:3084391 | lifeskim:mentions | umls-concept:C0205132 | lld:lifeskim |
| pubmed-article:3084391 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:3084391 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:3084391 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:3084391 | pubmed:dateCreated | 1986-6-12 | lld:pubmed |
| pubmed-article:3084391 | pubmed:abstractText | The establishment of IL-2-independent T-cell lines spontaneously derived from long-term IL-2-dependent cytotoxic T-cell lines is described. Two lines (cloned and uncloned) studied in detail have shown the following characteristics: (1) Permanent loss of IL-2 dependence. (2) Partial or complete loss of both cytotoxic activity and the IL-2 receptor. (3) Increased expression of T-cell membrane markers (Thy1.2, Lyt1.2) compared with the parental line. (4) Lower level of DNA methylation than in freshly obtained lymphoid cells. (5) Different karyotypic pattern from the parental IL-2-dependent line, with a mean number of 39-40 chromosomes and a resemblance to T leukemic lines. (6) Leukemia caused in normal syngeneic C57BL/6 mice by the uncloned line, in contrast to the cloned IL-2-independent line or the parental dependent line. Unlike established leukemic lines, however, the independent line gave rise to tumors which regressed in some mice within a few days of their appearance. These findings suggest that T-cell lines maintained with IL-2 for prolonged periods of time (greater than 3 months) can undergo transformation and, therefore, should not be utilized for immunotherapeutic purposes. | lld:pubmed |
| pubmed-article:3084391 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3084391 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3084391 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3084391 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3084391 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3084391 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3084391 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3084391 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3084391 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3084391 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3084391 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3084391 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3084391 | pubmed:month | May | lld:pubmed |
| pubmed-article:3084391 | pubmed:issn | 0020-7136 | lld:pubmed |
| pubmed-article:3084391 | pubmed:author | pubmed-author:ManiMM | lld:pubmed |
| pubmed-article:3084391 | pubmed:author | pubmed-author:KedarEE | lld:pubmed |
| pubmed-article:3084391 | pubmed:author | pubmed-author:RazinAA | lld:pubmed |
| pubmed-article:3084391 | pubmed:author | pubmed-author:SzycHH | lld:pubmed |
| pubmed-article:3084391 | pubmed:author | pubmed-author:Chriqui-Zeira... | lld:pubmed |
| pubmed-article:3084391 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3084391 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:3084391 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:3084391 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3084391 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3084391 | pubmed:pagination | 781-6 | lld:pubmed |
| pubmed-article:3084391 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:3084391 | pubmed:meshHeading | pubmed-meshheading:3084391-... | lld:pubmed |
| pubmed-article:3084391 | pubmed:meshHeading | pubmed-meshheading:3084391-... | lld:pubmed |
| pubmed-article:3084391 | pubmed:meshHeading | pubmed-meshheading:3084391-... | lld:pubmed |
| pubmed-article:3084391 | pubmed:meshHeading | pubmed-meshheading:3084391-... | lld:pubmed |
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| pubmed-article:3084391 | pubmed:meshHeading | pubmed-meshheading:3084391-... | lld:pubmed |
| pubmed-article:3084391 | pubmed:meshHeading | pubmed-meshheading:3084391-... | lld:pubmed |
| pubmed-article:3084391 | pubmed:meshHeading | pubmed-meshheading:3084391-... | lld:pubmed |
| pubmed-article:3084391 | pubmed:meshHeading | pubmed-meshheading:3084391-... | lld:pubmed |
| pubmed-article:3084391 | pubmed:meshHeading | pubmed-meshheading:3084391-... | lld:pubmed |
| pubmed-article:3084391 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3084391 | pubmed:articleTitle | Characterization of a tumorigenic murine T-lymphoid-cell line spontaneously derived from an IL-2-dependent T-cell line. | lld:pubmed |
| pubmed-article:3084391 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3084391 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3084391 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3084391 | lld:pubmed |
