| pubmed-article:3081885 | pubmed:abstractText | The sensitivity of pancreatic beta-cells to i. v. injection of glucose and arginine was determined in patients with insulin-independent diabetes mellitus (IIDM) of various duration and with different therapeutic response to sugar lowering drugs (SLD). In a group of healthy persons who were examined in a similar way, a peak rise of insulin was observed after injection of glucose and arginine. A peak rise of insulin after glucose administration was absent in patients managed with SLD, whereas an insulin level during the arginine test reached 302 +/- 12.7 pmol/l. In most of the patients showing resistance to SLD, who received insulin therapy after examination, a maximum insulin level value was 106 +/- 12.1 pmol/l only. Thus the arginine test can be used to state SLD therapy inefficacy and for substantiation of insulin therapy. | lld:pubmed |
