| pubmed-article:3080546 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3080546 | lifeskim:mentions | umls-concept:C0023467 | lld:lifeskim |
| pubmed-article:3080546 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:3080546 | lifeskim:mentions | umls-concept:C1512666 | lld:lifeskim |
| pubmed-article:3080546 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3080546 | pubmed:dateCreated | 1986-3-26 | lld:pubmed |
| pubmed-article:3080546 | pubmed:abstractText | The organization and expression of the beta chain of T cell antigen receptor gene (beta-TCR) and Ig H and L chain genes were analyzed by Southern blot technique in 24 patients with a diagnosis of acute myeloblastic leukemia (AML). Rearrangements of the beta-TCR genes were seen in DNA samples from 3 of the 24 patients. One of these three patients also showed rearrangement of the Ig H chain gene. RNA samples from all three patients expressed a beta-TCR gene transcript on dot blot analysis. However, on Northern blot analysis, one patient expressed an incomplete 1.0 kb transcript and no Ig H chain mRNA, despite a rearranged configuration. The karyotypes of two of these patients showed abnormalities involving chromosome 7. Rearrangements of T cell antigen receptor genes may occur in nonlymphoid malignancy, and is consistent with the concept of lineage infidelity in AML. | lld:pubmed |
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| pubmed-article:3080546 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3080546 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3080546 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3080546 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3080546 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:3080546 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:3080546 | pubmed:author | pubmed-author:McCullochE... | lld:pubmed |
| pubmed-article:3080546 | pubmed:author | pubmed-author:MaoT STS | lld:pubmed |
| pubmed-article:3080546 | pubmed:author | pubmed-author:ChengG YGY | lld:pubmed |
| pubmed-article:3080546 | pubmed:author | pubmed-author:MindenM DMD | lld:pubmed |
| pubmed-article:3080546 | pubmed:author | pubmed-author:ToyonagaBB | lld:pubmed |
| pubmed-article:3080546 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3080546 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:3080546 | pubmed:volume | 163 | lld:pubmed |
| pubmed-article:3080546 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3080546 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3080546 | pubmed:pagination | 414-24 | lld:pubmed |
| pubmed-article:3080546 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3080546 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3080546 | pubmed:articleTitle | T cell receptor and immunoglobulin gene rearrangements in acute myeloblastic leukemia. | lld:pubmed |
| pubmed-article:3080546 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3080546 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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