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pubmed-article:3056241pubmed:abstractTextStructure-activity relationships of phenazines against Mycobacterium leprae were investigated by using an in vitro radiorespirometric assay. In general, activity in ascending order was observed in compounds containing no chlorine atoms, a monochlorinated phenazine nucleus, and chlorines in the para positions of both the anilino and phenyl rings. The most active compounds contained a 2,2,6,6-tetramethylpiperidine substitution at the imino nitrogen. Most of these chlorinated phenazines were considerably more active in vitro than clofazimine (B663).lld:pubmed
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pubmed-article:3056241pubmed:articleTitleStructure-activity relationships of selected phenazines against Mycobacterium leprae in vitro.lld:pubmed
pubmed-article:3056241pubmed:affiliationGillis W. Long Hansen's Disease Center, Carville, Louisiana 70721.lld:pubmed
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