| pubmed-article:3049288 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3049288 | lifeskim:mentions | umls-concept:C0028754 | lld:lifeskim |
| pubmed-article:3049288 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:3049288 | lifeskim:mentions | umls-concept:C0010572 | lld:lifeskim |
| pubmed-article:3049288 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:3049288 | lifeskim:mentions | umls-concept:C0205178 | lld:lifeskim |
| pubmed-article:3049288 | lifeskim:mentions | umls-concept:C0073867 | lld:lifeskim |
| pubmed-article:3049288 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:3049288 | pubmed:dateCreated | 1988-11-22 | lld:pubmed |
| pubmed-article:3049288 | pubmed:abstractText | Acute treatment of ob/ob mice with S-carboxymethylated hGH (RCM-hGH), a diabetogenic derivative of GH which lacks significant insulin-like and growth-promoting activities, results in an increase in fasting plasma insulin and blood glucose levels and enhanced peripheral tissue insulin resistance. Plasma insulin level increases within 3 h after RCM-hGH is administered, whereas increased blood glucose concentration and enhanced peripheral tissue insulin resistance became evident 6 h after the hormone derivative is given. The lag period seen in the manifestation of these diabetogenic effects of RCM-hGH is consistent with the time required for gene expression. Therefore, the present study was undertaken to determine whether the above acute responses to the diabetogenic action of RCM-hGH would be expressed in ob/ob mice in which protein synthesis was blocked with cycloheximide. Female ob/ob mice were given either saline or cycloheximide (0.1 mg/g BW) ip and 1 h later were fasted and treated with either saline or 200 micrograms RCM-hGH ip. The mice were given a second injection of cycloheximide during the middle of the hormone treatment period to insure that protein synthesis remained blocked for the entire 6 h. In the animals not receiving cycloheximide, fasting plasma insulin level and blood glucose concentration were markedly elevated 6 h after the injection of RCM-hGH. Also, the GH derivative attenuated the ability of insulin added in vitro to stimulate glucose oxidation by adipose tissue segments isolated from the animals.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:3049288 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3049288 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3049288 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3049288 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3049288 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3049288 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3049288 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3049288 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3049288 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3049288 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3049288 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3049288 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:3049288 | pubmed:issn | 0018-5043 | lld:pubmed |
| pubmed-article:3049288 | pubmed:author | pubmed-author:CameronC MCM | lld:pubmed |
| pubmed-article:3049288 | pubmed:author | pubmed-author:KostyoJ LJL | lld:pubmed |
| pubmed-article:3049288 | pubmed:author | pubmed-author:AdamafioN ANA | lld:pubmed |
| pubmed-article:3049288 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3049288 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:3049288 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3049288 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3049288 | pubmed:pagination | 391-4 | lld:pubmed |
| pubmed-article:3049288 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:3049288 | pubmed:meshHeading | pubmed-meshheading:3049288-... | lld:pubmed |
| pubmed-article:3049288 | pubmed:meshHeading | pubmed-meshheading:3049288-... | lld:pubmed |
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| pubmed-article:3049288 | pubmed:meshHeading | pubmed-meshheading:3049288-... | lld:pubmed |
| pubmed-article:3049288 | pubmed:meshHeading | pubmed-meshheading:3049288-... | lld:pubmed |
| pubmed-article:3049288 | pubmed:meshHeading | pubmed-meshheading:3049288-... | lld:pubmed |
| pubmed-article:3049288 | pubmed:meshHeading | pubmed-meshheading:3049288-... | lld:pubmed |
| pubmed-article:3049288 | pubmed:meshHeading | pubmed-meshheading:3049288-... | lld:pubmed |
| pubmed-article:3049288 | pubmed:meshHeading | pubmed-meshheading:3049288-... | lld:pubmed |
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| pubmed-article:3049288 | pubmed:meshHeading | pubmed-meshheading:3049288-... | lld:pubmed |
| pubmed-article:3049288 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3049288 | pubmed:articleTitle | Influence of cycloheximide on acute diabetogenic effects of S-carboxymethylated human growth hormone in obese (ob/ob) mice. | lld:pubmed |
| pubmed-article:3049288 | pubmed:affiliation | Department of Physiology, University of Michigan Medical School, Ann Arbor. | lld:pubmed |
| pubmed-article:3049288 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3049288 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3049288 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
