| pubmed-article:304874 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:304874 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:304874 | lifeskim:mentions | umls-concept:C0022686 | lld:lifeskim |
| pubmed-article:304874 | lifeskim:mentions | umls-concept:C1510827 | lld:lifeskim |
| pubmed-article:304874 | lifeskim:mentions | umls-concept:C0205251 | lld:lifeskim |
| pubmed-article:304874 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:304874 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:304874 | pubmed:dateCreated | 1978-4-26 | lld:pubmed |
| pubmed-article:304874 | pubmed:abstractText | Human T lymphocytes were separated into two subsets on the basis of relative affinity for sheep red blood cells (E), and these T cell fractions were examined for cytotoxic reactivity against antibody-sensitized Change liver cells (ADCC). High affinity E-rosette-forming cells (E-RFC) (55 +/- 6% of peripheral blood mononuclear cells), capable of rosette formation despite elevated temperatures of incubation (29 degrees C) and a limited concentration of E, contained few antibody-dependent cytotoxic cells (K cells). In contrast, low affinity E-RFC (23+/-7% of mononuclear cell suspensions) requiring cool temperatures of incubation (4 degrees C) and an excess of E to form rosettes, were highly enriched for ADCC activity. The majority of K cells exhibited low affinity interactions with E. T cells in thymus, tonsil, and lymph node formed high affinity E-rosettes and exhibited little reactivity in ADCC. Only peripheral blood and spleen contained easily identified low affinity E-RFC and anti-body-dependent cytotoxic cells. The proportion of low affinity E-RFC in the peripheral blood of normal subjects correlated closely with reactivity in ADCC, making it possible to predict cytotoxic potential for the E-rosette pattern. These data indicate that the human K cell may belong to a previously unappreciated but functionally important subset of thymic dependent mononuclear cells. | lld:pubmed |
| pubmed-article:304874 | pubmed:language | eng | lld:pubmed |
| pubmed-article:304874 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:304874 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:304874 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:304874 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:304874 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:304874 | pubmed:author | pubmed-author:HerbermanR... | lld:pubmed |
| pubmed-article:304874 | pubmed:author | pubmed-author:WestW HWH | lld:pubmed |
| pubmed-article:304874 | pubmed:author | pubmed-author:BoozerR BRB | lld:pubmed |
| pubmed-article:304874 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:304874 | pubmed:volume | 120 | lld:pubmed |
| pubmed-article:304874 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:304874 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:304874 | pubmed:pagination | 90-5 | lld:pubmed |
| pubmed-article:304874 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:304874 | pubmed:meshHeading | pubmed-meshheading:304874-K... | lld:pubmed |
| pubmed-article:304874 | pubmed:year | 1978 | lld:pubmed |
| pubmed-article:304874 | pubmed:articleTitle | Low affinity E-rosette formation by the human K cell. | lld:pubmed |
| pubmed-article:304874 | pubmed:publicationType | Journal Article | lld:pubmed |
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