| pubmed-article:3040424 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3040424 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:3040424 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:3040424 | lifeskim:mentions | umls-concept:C0312738 | lld:lifeskim |
| pubmed-article:3040424 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:3040424 | lifeskim:mentions | umls-concept:C0031437 | lld:lifeskim |
| pubmed-article:3040424 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:3040424 | lifeskim:mentions | umls-concept:C1420192 | lld:lifeskim |
| pubmed-article:3040424 | lifeskim:mentions | umls-concept:C1553412 | lld:lifeskim |
| pubmed-article:3040424 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:3040424 | lifeskim:mentions | umls-concept:C1548328 | lld:lifeskim |
| pubmed-article:3040424 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:3040424 | pubmed:dateCreated | 1987-10-9 | lld:pubmed |
| pubmed-article:3040424 | pubmed:abstractText | A series of lymphoblastoid cell lines (LCLs) have been established by in vitro infection of fetal bone marrow and fetal liver cells with Epstein-Barr virus (EBV). While most lines showed the usual mature B cell phenotype, a small proportion were cytoplasmic and surface immunoglobulin (Ig) heavy and light chain negative. Analysis of gene rearrangements indicated that the Ig- lines were either germ-line or nonproductively rearranged when probed for JH and were in germ-line configuration for C chi; no mu or chi mRNA could be detected in such cells. Precursor B cell lines were indistinguishable from their normal Ig+ counterparts in their expression of a wide variety of cell surface markers including "activation" antigens usually associated with the lymphoblastoid state; even the single LCL showing germ-line heavy and light chain genes expressed B lineage-specific cell surface antigens. However, the Ig- lines were distinct from their Ig+ counterparts in three important respects: (a) they grew much more slowly and achieved lower saturation densities, (b) they showed unusually high proportions (8-16%) of cells in EBV-productive cycle, and (c) they contained unusually high proportions (up to 40%) of cells expressing free joining (J) chain. These results suggest that precursor B cells differ in their response to the growth-transforming effects of EBV such that the virus-cell interaction in precursor B cell lines is inherently less stable than in conventional LCL. In particular there may be a greater movement of cells out of cycle and along the B cell maturation pathway. It is possible that such movement leads in individual cells either to virus replication or to a "sterile" plasmacytoid differentiation with J chain expression in the absence of Ig synthesis. | lld:pubmed |
| pubmed-article:3040424 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3040424 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3040424 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3040424 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3040424 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3040424 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3040424 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3040424 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:3040424 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:3040424 | pubmed:author | pubmed-author:YoungL SLS | lld:pubmed |
| pubmed-article:3040424 | pubmed:author | pubmed-author:RabbittsT HTH | lld:pubmed |
| pubmed-article:3040424 | pubmed:author | pubmed-author:ForsterAA | lld:pubmed |
| pubmed-article:3040424 | pubmed:author | pubmed-author:RickinsonA... | lld:pubmed |
| pubmed-article:3040424 | pubmed:author | pubmed-author:RoweMM | lld:pubmed |
| pubmed-article:3040424 | pubmed:author | pubmed-author:GregoryC DCD | lld:pubmed |
| pubmed-article:3040424 | pubmed:author | pubmed-author:EdwardsC FCF | lld:pubmed |
| pubmed-article:3040424 | pubmed:author | pubmed-author:KirchgensCC | lld:pubmed |
| pubmed-article:3040424 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3040424 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:3040424 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3040424 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3040424 | pubmed:pagination | 1199-207 | lld:pubmed |
| pubmed-article:3040424 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:3040424 | pubmed:meshHeading | pubmed-meshheading:3040424-... | lld:pubmed |
| pubmed-article:3040424 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3040424 | pubmed:articleTitle | Epstein-Barr virus-transformed human precursor B cell lines: altered growth phenotype of lines with germ-line or rearranged but nonexpressed heavy chain genes. | lld:pubmed |
| pubmed-article:3040424 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3040424 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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