| pubmed-article:3039515 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3039515 | lifeskim:mentions | umls-concept:C0000742 | lld:lifeskim |
| pubmed-article:3039515 | lifeskim:mentions | umls-concept:C0018895 | lld:lifeskim |
| pubmed-article:3039515 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:3039515 | lifeskim:mentions | umls-concept:C0040682 | lld:lifeskim |
| pubmed-article:3039515 | lifeskim:mentions | umls-concept:C0332197 | lld:lifeskim |
| pubmed-article:3039515 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:3039515 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:3039515 | pubmed:dateCreated | 1987-9-18 | lld:pubmed |
| pubmed-article:3039515 | pubmed:abstractText | We investigated the role of the Moloney helper virus, Moloney murine leukemia virus (Mo-MuLV), in cell transformation and tumor induction by the defective Abelson murine leukemia virus (Ab-MuLV). A molecular clone of Ab-MuLV (P160 strain) was transfected into the psi 2 packaging cell line, and helper virus-free Ab-MuLV (psi 2) was harvested from the supernatant medium. Ab-MuLV (psi 2) was as efficient as helper virus-containing Ab-MuLV (Mo-MuLV) in the transformation of primary bone marrow cells in vitro. Inoculation of weanling BALB/c mice with Ab-MuLV (psi 2) induced nonthymic pre-B-cell lymphomas with high efficiency and short latency (28 days). Adult BALB/c mice were less sensitive to tumor induction by a factor of 100. Ab-MuLV (psi 2) did not induce tumors in weanling C57BL/6 mice, unlike Ab-MuLV (Mo-MuLV). Examination of the proviral integration pattern in Ab-MuLV (psi 2)-induced tumor cell DNA revealed that each of the tumors contained a single integrated provirus. Immunoprecipitation of viral-encoded proteins in helper virus-free tumor cell lines detected the P160 Ab-MuLV-transforming protein; however, no trace of the gag, pol, and env helper virus-encoded proteins was found. Our results indicate that integration and expression of a single Ab-MuLV genome is sufficient for efficient transformation of primary bone marrow cells by Ab-MuLV in vitro and tumor induction in susceptible mice. However, the helper virus may contribute to tumor induction in weanling resistant mice. | lld:pubmed |
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| pubmed-article:3039515 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3039515 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3039515 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3039515 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3039515 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:3039515 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:3039515 | pubmed:author | pubmed-author:RisserRR | lld:pubmed |
| pubmed-article:3039515 | pubmed:author | pubmed-author:KaehlerD ADA | lld:pubmed |
| pubmed-article:3039515 | pubmed:author | pubmed-author:GreenP LPL | lld:pubmed |
| pubmed-article:3039515 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3039515 | pubmed:volume | 84 | lld:pubmed |
| pubmed-article:3039515 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3039515 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3039515 | pubmed:pagination | 5932-6 | lld:pubmed |
| pubmed-article:3039515 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3039515 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3039515 | pubmed:articleTitle | Cell transformation and tumor induction by Abelson murine leukemia virus in the absence of helper virus. | lld:pubmed |
| pubmed-article:3039515 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3039515 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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