| pubmed-article:3039352 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3039352 | lifeskim:mentions | umls-concept:C0000742 | lld:lifeskim |
| pubmed-article:3039352 | lifeskim:mentions | umls-concept:C1510411 | lld:lifeskim |
| pubmed-article:3039352 | lifeskim:mentions | umls-concept:C0021764 | lld:lifeskim |
| pubmed-article:3039352 | lifeskim:mentions | umls-concept:C0205132 | lld:lifeskim |
| pubmed-article:3039352 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:3039352 | pubmed:dateCreated | 1987-9-23 | lld:pubmed |
| pubmed-article:3039352 | pubmed:abstractText | Abelson murine leukemia virus (A-MuLV) carries the gene v-abl, one of a group of oncogenes with structural and functional (tyrosine kinase) homology to three growth factor receptors. Work in this and other laboratories has shown that A-MuLV infection can render myeloid and lymphoid cells independent of the growth factors interleukin 3 and granulocyte-macrophage colony-stimulating factor. We have now shown that v-abl can also relieve interleukin 2 (IL-2) dependence in T cells. We infected a cloned IL-2-dependent antigen-specific cell line. Transformed cells were generated which were factor independent and tumorigenic. The transformants each bore unique v-abl DNA inserts and expressed v-abl mRNA. No elevation of expression of either IL-2 or its receptor could be detected in these cells. Thus, A-MuLV can short-circuit the dependence of hematopoietic cells on IL-2, IL-3, and possibly granulocyte-macrophage colony-stimulating factor, none of whose receptors are known to be of the tyrosine kinase type. | lld:pubmed |
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| pubmed-article:3039352 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:3039352 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3039352 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3039352 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:3039352 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:3039352 | pubmed:author | pubmed-author:MacDonaldH... | lld:pubmed |
| pubmed-article:3039352 | pubmed:author | pubmed-author:MillerJ FJF | lld:pubmed |
| pubmed-article:3039352 | pubmed:author | pubmed-author:FilaKK | lld:pubmed |
| pubmed-article:3039352 | pubmed:author | pubmed-author:PORTEOUSDD | lld:pubmed |
| pubmed-article:3039352 | pubmed:author | pubmed-author:GabathulerRR | lld:pubmed |
| pubmed-article:3039352 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3039352 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:3039352 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3039352 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3039352 | pubmed:pagination | 2631-5 | lld:pubmed |
| pubmed-article:3039352 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3039352 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3039352 | pubmed:articleTitle | Abelson virus transformation of an interleukin 2-dependent antigen-specific T-cell line. | lld:pubmed |
| pubmed-article:3039352 | pubmed:publicationType | Journal Article | lld:pubmed |
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