| pubmed-article:3037064 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3037064 | lifeskim:mentions | umls-concept:C0085979 | lld:lifeskim |
| pubmed-article:3037064 | lifeskim:mentions | umls-concept:C0001643 | lld:lifeskim |
| pubmed-article:3037064 | lifeskim:mentions | umls-concept:C0018792 | lld:lifeskim |
| pubmed-article:3037064 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:3037064 | lifeskim:mentions | umls-concept:C0597358 | lld:lifeskim |
| pubmed-article:3037064 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:3037064 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:3037064 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:3037064 | pubmed:dateCreated | 1987-7-30 | lld:pubmed |
| pubmed-article:3037064 | pubmed:abstractText | The selective beta-2 adrenoceptor agonist procaterol produced positive inotropic and chronotropic responses over a concentration range of 1 nM to 0.1 mM in spontaneously beating right atria and in three of seven electrically driven left atria. The pD2 values (right atria, 7.30; left atria, 7.18) were midway between its known affinities at beta-1 and beta-2 adrenoceptors and are evidence that positive inotropic and chronotropic responses involve a minor beta-2 adrenoceptor component. The pKB values for procaterol against (-)-isoproterenol in the right atria (5.59) and left atria (5.29) were consistent with its affinity for beta-1 adrenoceptors and suggest that these are responsible primarily for positive inotropic and chronotropic responses. Receptor binding studies in right atrial homogenates showed that [125I]cyanopindolol binding was saturable (KD = 36.2 pM, maximal density of binding sites = 49.2 fmol mg-1 protein) and stereoselective with respect to the isomers of propranolol. Competition binding curves for the beta-1 adrenoceptor antagonist CGP 20712A and beta-2 selective antagonist ICI 118,551 against [125I]cyanopindolol binding were resolved into two components using iterative curve fitting techniques. Binding sites with the characteristics of beta-1 and beta-2 adrenoceptors were present in the proportions of approximately 75 to 25%. These studies indicate either that the beta-1 adrenoceptor is coupled more efficiently to the positive inotropic and chronotropic response than the beta-2 adrenoceptor or that a proportion of the beta-2 adrenoceptors subserve other functions. | lld:pubmed |
| pubmed-article:3037064 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3037064 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3037064 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3037064 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3037064 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:3037064 | pubmed:issn | 0022-3565 | lld:pubmed |
| pubmed-article:3037064 | pubmed:author | pubmed-author:SummersR JRJ | lld:pubmed |
| pubmed-article:3037064 | pubmed:author | pubmed-author:MolenaarPP | lld:pubmed |
| pubmed-article:3037064 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3037064 | pubmed:volume | 241 | lld:pubmed |
| pubmed-article:3037064 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3037064 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3037064 | pubmed:pagination | 1041-7 | lld:pubmed |
| pubmed-article:3037064 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:3037064 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3037064 | pubmed:articleTitle | Characterization of beta-1 and beta-2 adrenoceptors in guinea pig atrium: functional and receptor binding studies. | lld:pubmed |
| pubmed-article:3037064 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3037064 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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