| pubmed-article:3035704 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3035704 | lifeskim:mentions | umls-concept:C0227525 | lld:lifeskim |
| pubmed-article:3035704 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:3035704 | lifeskim:mentions | umls-concept:C1879725 | lld:lifeskim |
| pubmed-article:3035704 | lifeskim:mentions | umls-concept:C1158360 | lld:lifeskim |
| pubmed-article:3035704 | pubmed:dateCreated | 1987-7-22 | lld:pubmed |
| pubmed-article:3035704 | pubmed:abstractText | The oxidation and esterification of 14C labelled eicosapentaenoic acid (20:5,n-3) and arachidonic acid (20:4,n-6) in isolated liver cells has been studied. The bioconversion of C18 and C22 polyunsaturated fatty acids to 20:5(n-3) and 20:4(n-6) is also discussed. Adrenic acid (22:4,n-6) and docosahexaenoic acid (22:6,n-3) are retroconverted to 20:4(n-6) and 20:5(n-3) respectively by peroxisomal beta-oxidation. 20:4(n-6) and 20:5(n-3) are both mainly oxidized in the mitochondria. The peroxisomal contribution to the oxidation of 20:5,n-3 is however larger than with 18:2(n-6) and 18:1(n-9) which are predominantly oxidized by mitochondrial beta-oxidation. Isolated liver cells oxidize more 20:5(n-3) and esterify less than observed with 20:4(n-6) as substrate. In liver cells from essential fatty acid deficient animals 20:5(n-3) and 20:4(n-6) are both efficiently directed to the phospholipids. In hepatocytes from animals fed a diet rich in 18:2(n-6) and 18:3(n-3) arachidonic acid is still to a large extent esterified in the phospholipids while 20:5(n-3) only to a small extent is esterified in this lipid fraction. 18:2(n-6) is much more efficiently esterified in the phospholipids than is 18:3(n-3) which is also rapidly removed from the phospholipids. The delta 4 desaturase activity is increased in essential fatty acid deficiency similar to delta 6 desaturase. The competition between 18:3(n-3) and 18:2(n-6) for delta 6 desaturation in combination with a much higher dietary intake of 18:2(n-6) than of 18:3(n-3) may limit the conversion of dietary 18:3(n-3) to 20:5(n-3).(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:3035704 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3035704 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3035704 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3035704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3035704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3035704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3035704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3035704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3035704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3035704 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3035704 | pubmed:issn | 0085-591X | lld:pubmed |
| pubmed-article:3035704 | pubmed:author | pubmed-author:ChristensenEE | lld:pubmed |
| pubmed-article:3035704 | pubmed:author | pubmed-author:Christopherse... | lld:pubmed |
| pubmed-article:3035704 | pubmed:author | pubmed-author:HagveT ATA | lld:pubmed |
| pubmed-article:3035704 | pubmed:author | pubmed-author:JohansenYY | lld:pubmed |
| pubmed-article:3035704 | pubmed:author | pubmed-author:TverdalSS | lld:pubmed |
| pubmed-article:3035704 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3035704 | pubmed:volume | 184 | lld:pubmed |
| pubmed-article:3035704 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3035704 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3035704 | pubmed:pagination | 55-60 | lld:pubmed |
| pubmed-article:3035704 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3035704 | pubmed:meshHeading | pubmed-meshheading:3035704-... | lld:pubmed |
| pubmed-article:3035704 | pubmed:meshHeading | pubmed-meshheading:3035704-... | lld:pubmed |
| pubmed-article:3035704 | pubmed:meshHeading | pubmed-meshheading:3035704-... | lld:pubmed |
| pubmed-article:3035704 | pubmed:meshHeading | pubmed-meshheading:3035704-... | lld:pubmed |
| pubmed-article:3035704 | pubmed:meshHeading | pubmed-meshheading:3035704-... | lld:pubmed |
| pubmed-article:3035704 | pubmed:meshHeading | pubmed-meshheading:3035704-... | lld:pubmed |
| pubmed-article:3035704 | pubmed:meshHeading | pubmed-meshheading:3035704-... | lld:pubmed |
| pubmed-article:3035704 | pubmed:meshHeading | pubmed-meshheading:3035704-... | lld:pubmed |
| pubmed-article:3035704 | pubmed:meshHeading | pubmed-meshheading:3035704-... | lld:pubmed |
| pubmed-article:3035704 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3035704 | pubmed:articleTitle | Eicosapentaenoic- and arachidonic acid metabolism in isolated liver cells. | lld:pubmed |
| pubmed-article:3035704 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3035704 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:3035704 | pubmed:publicationType | Review | lld:pubmed |
