| pubmed-article:3029565 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3029565 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:3029565 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:3029565 | lifeskim:mentions | umls-concept:C0333714 | lld:lifeskim |
| pubmed-article:3029565 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:3029565 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:3029565 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:3029565 | lifeskim:mentions | umls-concept:C1709634 | lld:lifeskim |
| pubmed-article:3029565 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3029565 | pubmed:dateCreated | 1987-4-15 | lld:pubmed |
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| pubmed-article:3029565 | pubmed:abstractText | An in vitro culture of FLEB14 cells, an Epstein-Barr virus-transformed B cell precursor containing the germ line immunoglobulin genes, gave rise to a uniclonally expanded variant, FLEB14 delta 3, which was rearranged at the immunoglobulin heavy-chain gene locus. Cytogenetic analysis showed that FLEB14 delta 3 had a novel reciprocal translocation, t(6;14)(q15;q32). Molecular cloning of the rearranged DNA fragments and determination of their nucleotide sequence revealed that the recombination event was reciprocal, imprecise, and nonhomologous and took place in the S mu region, like those found in Burkitt's lymphoma cells. We propose a molecular model to explain this genetic event which may be relevant to class switch recombination. The translocated sequence of chromosome 6 did not contain any known oncogenes, although the sequence is conserved among mammals. FLEB14 delta 3 did not show tumorigenicity. | lld:pubmed |
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| pubmed-article:3029565 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3029565 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3029565 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3029565 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3029565 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:3029565 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:3029565 | pubmed:author | pubmed-author:KleinGG | lld:pubmed |
| pubmed-article:3029565 | pubmed:author | pubmed-author:OnoYY | lld:pubmed |
| pubmed-article:3029565 | pubmed:author | pubmed-author:HonjoTT | lld:pubmed |
| pubmed-article:3029565 | pubmed:author | pubmed-author:UnoMM | lld:pubmed |
| pubmed-article:3029565 | pubmed:author | pubmed-author:YamakiMM | lld:pubmed |
| pubmed-article:3029565 | pubmed:author | pubmed-author:SasakiM SMS | lld:pubmed |
| pubmed-article:3029565 | pubmed:author | pubmed-author:OtsuMM | lld:pubmed |
| pubmed-article:3029565 | pubmed:author | pubmed-author:KatamineSS | lld:pubmed |
| pubmed-article:3029565 | pubmed:author | pubmed-author:YaoitaYY | lld:pubmed |
| pubmed-article:3029565 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3029565 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:3029565 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3029565 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3029565 | pubmed:pagination | 708-17 | lld:pubmed |
| pubmed-article:3029565 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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