pubmed-article:3029561 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:3029561 | lifeskim:mentions | umls-concept:C0087140 | lld:lifeskim |
pubmed-article:3029561 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
pubmed-article:3029561 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
pubmed-article:3029561 | lifeskim:mentions | umls-concept:C0033634 | lld:lifeskim |
pubmed-article:3029561 | lifeskim:mentions | umls-concept:C0443224 | lld:lifeskim |
pubmed-article:3029561 | lifeskim:mentions | umls-concept:C0035253 | lld:lifeskim |
pubmed-article:3029561 | lifeskim:mentions | umls-concept:C1293122 | lld:lifeskim |
pubmed-article:3029561 | lifeskim:mentions | umls-concept:C0205615 | lld:lifeskim |
pubmed-article:3029561 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
pubmed-article:3029561 | pubmed:issue | 2 | lld:pubmed |
pubmed-article:3029561 | pubmed:dateCreated | 1987-4-15 | lld:pubmed |
pubmed-article:3029561 | pubmed:abstractText | Expression of c-fos mRNA was investigated in fresh, normal peritoneal macrophages (M phi), which are terminally differentiated, nonproliferating cells. The levels of c-fos mRNA were dramatically increased by stimulation with phorbol myristate acetate (PMA), calcium ionophore, or 1-oleoyl-2-acetoyl glycerol (OAG). Induction of c-fos mRNA by all the above agents followed similar kinetics, with a peak of mRNA 30 min after stimulation. These results demonstrate that c-fos mRNA can be augmented in fresh, terminally differentiated cells. Since the stimuli increasing c-fos mRNA are direct or indirect activators of protein kinase C, our data suggest that in M phi c-fos mRNA is controlled by protein kinase C activation. PMA, calcium ionophore, and OAG were biologically active in M phi. PMA and calcium ionophore induced respiratory burst and tumoricidal activity, respectively, whereas OAG and PMA were chemotactic for M phi. Interferons beta and gamma, potent M phi activators eliciting tumoricidal activity, did not alter the levels of c-fos mRNA. These results indicate that c-fos mRNA augmentation is a stimulus-specific rather than a function-specific response connected to activation of protein kinase C. | lld:pubmed |
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pubmed-article:3029561 | pubmed:language | eng | lld:pubmed |
pubmed-article:3029561 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3029561 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:3029561 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:3029561 | pubmed:month | Feb | lld:pubmed |
pubmed-article:3029561 | pubmed:issn | 0270-7306 | lld:pubmed |
pubmed-article:3029561 | pubmed:author | pubmed-author:VaresioLL | lld:pubmed |
pubmed-article:3029561 | pubmed:author | pubmed-author:BottazziBB | lld:pubmed |
pubmed-article:3029561 | pubmed:author | pubmed-author:RadziochDD | lld:pubmed |
pubmed-article:3029561 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:3029561 | pubmed:volume | 7 | lld:pubmed |
pubmed-article:3029561 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:3029561 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:3029561 | pubmed:pagination | 595-9 | lld:pubmed |
pubmed-article:3029561 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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pubmed-article:3029561 | pubmed:year | 1987 | lld:pubmed |
pubmed-article:3029561 | pubmed:articleTitle | Augmentation of c-fos mRNA expression by activators of protein kinase C in fresh, terminally differentiated resting macrophages. | lld:pubmed |
pubmed-article:3029561 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:3029561 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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