| pubmed-article:3029281 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3029281 | lifeskim:mentions | umls-concept:C0521026 | lld:lifeskim |
| pubmed-article:3029281 | lifeskim:mentions | umls-concept:C0086312 | lld:lifeskim |
| pubmed-article:3029281 | lifeskim:mentions | umls-concept:C0025932 | lld:lifeskim |
| pubmed-article:3029281 | lifeskim:mentions | umls-concept:C0011304 | lld:lifeskim |
| pubmed-article:3029281 | lifeskim:mentions | umls-concept:C0546816 | lld:lifeskim |
| pubmed-article:3029281 | lifeskim:mentions | umls-concept:C0376518 | lld:lifeskim |
| pubmed-article:3029281 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:3029281 | pubmed:dateCreated | 1987-4-1 | lld:pubmed |
| pubmed-article:3029281 | pubmed:abstractText | Adoptive transfer experiments in athymic nude mice demonstrated that the demyelination seen in the central nervous system (CNS) following Semliki Forest virus (SFV) infection was directly dependent upon sensitized T lymphocytes. Antibodies generated during the infection did not seem to be involved in the demyelination, but thymus-dependent antibodies (IgG) were responsible for the reduction of brain virus titres. In the absence of a T cell response and T cell-dependent antibody production, virus persisted in the CNS for several months. Despite persistence of high virus titres for this time, only mice eventually developing a CNS inflammatory response developed lesions of demyelination. In the absence of an inflammatory response no demyelination was apparent even after several months of persistent infection. Administration of anti-SFV hyperimmune serum intracerebrally to both infected and control mice did not produce demyelination but resulted in CNS tissue degeneration with marked pycnosis. | lld:pubmed |
| pubmed-article:3029281 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3029281 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3029281 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3029281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3029281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3029281 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3029281 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:3029281 | pubmed:issn | 0022-1317 | lld:pubmed |
| pubmed-article:3029281 | pubmed:author | pubmed-author:WebbH EHE | lld:pubmed |
| pubmed-article:3029281 | pubmed:author | pubmed-author:FazakerleyJ... | lld:pubmed |
| pubmed-article:3029281 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3029281 | pubmed:volume | 68 ( Pt 2) | lld:pubmed |
| pubmed-article:3029281 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3029281 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3029281 | pubmed:pagination | 377-85 | lld:pubmed |
| pubmed-article:3029281 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3029281 | pubmed:meshHeading | pubmed-meshheading:3029281-... | lld:pubmed |
| pubmed-article:3029281 | pubmed:meshHeading | pubmed-meshheading:3029281-... | lld:pubmed |
| pubmed-article:3029281 | pubmed:meshHeading | pubmed-meshheading:3029281-... | lld:pubmed |
| pubmed-article:3029281 | pubmed:meshHeading | pubmed-meshheading:3029281-... | lld:pubmed |
| pubmed-article:3029281 | pubmed:meshHeading | pubmed-meshheading:3029281-... | lld:pubmed |
| pubmed-article:3029281 | pubmed:meshHeading | pubmed-meshheading:3029281-... | lld:pubmed |
| pubmed-article:3029281 | pubmed:meshHeading | pubmed-meshheading:3029281-... | lld:pubmed |
| pubmed-article:3029281 | pubmed:meshHeading | pubmed-meshheading:3029281-... | lld:pubmed |
| pubmed-article:3029281 | pubmed:meshHeading | pubmed-meshheading:3029281-... | lld:pubmed |
| pubmed-article:3029281 | pubmed:meshHeading | pubmed-meshheading:3029281-... | lld:pubmed |
| pubmed-article:3029281 | pubmed:meshHeading | pubmed-meshheading:3029281-... | lld:pubmed |
| pubmed-article:3029281 | pubmed:meshHeading | pubmed-meshheading:3029281-... | lld:pubmed |
| pubmed-article:3029281 | pubmed:meshHeading | pubmed-meshheading:3029281-... | lld:pubmed |
| pubmed-article:3029281 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3029281 | pubmed:articleTitle | Semliki Forest virus-induced, immune-mediated demyelination: adoptive transfer studies and viral persistence in nude mice. | lld:pubmed |
| pubmed-article:3029281 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3029281 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3029281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3029281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3029281 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3029281 | lld:pubmed |
