| pubmed-article:3027304 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3027304 | lifeskim:mentions | umls-concept:C0001811 | lld:lifeskim |
| pubmed-article:3027304 | lifeskim:mentions | umls-concept:C0038435 | lld:lifeskim |
| pubmed-article:3027304 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:3027304 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:3027304 | lifeskim:mentions | umls-concept:C0023517 | lld:lifeskim |
| pubmed-article:3027304 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:3027304 | lifeskim:mentions | umls-concept:C0034785 | lld:lifeskim |
| pubmed-article:3027304 | lifeskim:mentions | umls-concept:C0013081 | lld:lifeskim |
| pubmed-article:3027304 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:3027304 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:3027304 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:3027304 | pubmed:dateCreated | 1987-2-27 | lld:pubmed |
| pubmed-article:3027304 | pubmed:abstractText | In vitro incubation of mononuclear leukocytes (MNL) with catecholamines desensitizes beta adrenergic receptors, meaning isoproterenol-stimulated cyclic AMP accumulation decreases. This desensitization is accompanied by two patterns of receptor changes: first, reduction of surface receptors (defined as binding of [3H]dihydroalprenolol inhibited by 1 microM CGP 12177 [4-3-tertiarybutylamino-2-hydroxypropoxy)-benzimidazole- 2-on-hydrochloride]) without any change in the total number of [3H] dihydroalprenolol binding sites inhibited by 1 microM propranolol (receptor redistribution); then reduction of the total number of receptors (receptor down-regulation). In the present study we investigated receptor redistribution and down-regulation under physiological conditions by raising endogenous catecholamines in the rat by stress. In young rats a single immobilization stress induced MNL beta adrenergic receptor redistribution: the number of surface receptors was reduced by about 50% but the total number remained the same. Receptor redistribution was prevented completely in rats pretreated with beta-blocking nadolol. Repeated stress down-regulated the MNL beta adrenergic receptors as shown by a reduction in the total number of sites. We also investigated the regulation of beta adrenergic receptors in three age-groups. After 60 min of immobilization stress the number of MNL surface receptors was reduced in young (4-month-old) rats but not in mature (12-month-old) or aged (26-month-old) rats. Using an alternative stress procedure, after single or repeated open-field sessions, we found receptor redistribution and down-regulation, respectively, in young rats. None of these adaptive receptor response was observed in 26-month-old rats.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:3027304 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3027304 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3027304 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3027304 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3027304 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3027304 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3027304 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3027304 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3027304 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3027304 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3027304 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3027304 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:3027304 | pubmed:issn | 0022-3565 | lld:pubmed |
| pubmed-article:3027304 | pubmed:author | pubmed-author:WieloszMM | lld:pubmed |
| pubmed-article:3027304 | pubmed:author | pubmed-author:De BlasiAA | lld:pubmed |
| pubmed-article:3027304 | pubmed:author | pubmed-author:FratelliMM | lld:pubmed |
| pubmed-article:3027304 | pubmed:author | pubmed-author:LipartitiMM | lld:pubmed |
| pubmed-article:3027304 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3027304 | pubmed:volume | 240 | lld:pubmed |
| pubmed-article:3027304 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3027304 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3027304 | pubmed:pagination | 228-33 | lld:pubmed |
| pubmed-article:3027304 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:3027304 | pubmed:meshHeading | pubmed-meshheading:3027304-... | lld:pubmed |
| pubmed-article:3027304 | pubmed:meshHeading | pubmed-meshheading:3027304-... | lld:pubmed |
| pubmed-article:3027304 | pubmed:meshHeading | pubmed-meshheading:3027304-... | lld:pubmed |
| pubmed-article:3027304 | pubmed:meshHeading | pubmed-meshheading:3027304-... | lld:pubmed |
| pubmed-article:3027304 | pubmed:meshHeading | pubmed-meshheading:3027304-... | lld:pubmed |
| pubmed-article:3027304 | pubmed:meshHeading | pubmed-meshheading:3027304-... | lld:pubmed |
| pubmed-article:3027304 | pubmed:meshHeading | pubmed-meshheading:3027304-... | lld:pubmed |
| pubmed-article:3027304 | pubmed:meshHeading | pubmed-meshheading:3027304-... | lld:pubmed |
| pubmed-article:3027304 | pubmed:meshHeading | pubmed-meshheading:3027304-... | lld:pubmed |
| pubmed-article:3027304 | pubmed:meshHeading | pubmed-meshheading:3027304-... | lld:pubmed |
| pubmed-article:3027304 | pubmed:meshHeading | pubmed-meshheading:3027304-... | lld:pubmed |
| pubmed-article:3027304 | pubmed:meshHeading | pubmed-meshheading:3027304-... | lld:pubmed |
| pubmed-article:3027304 | pubmed:meshHeading | pubmed-meshheading:3027304-... | lld:pubmed |
| pubmed-article:3027304 | pubmed:meshHeading | pubmed-meshheading:3027304-... | lld:pubmed |
| pubmed-article:3027304 | pubmed:meshHeading | pubmed-meshheading:3027304-... | lld:pubmed |
| pubmed-article:3027304 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3027304 | pubmed:articleTitle | Regulation of beta adrenergic receptors on rat mononuclear leukocytes by stress: receptor redistribution and down-regulation are altered with aging. | lld:pubmed |
| pubmed-article:3027304 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3027304 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3027304 | lld:pubmed |
