| pubmed-article:3023963 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3023963 | lifeskim:mentions | umls-concept:C0034802 | lld:lifeskim |
| pubmed-article:3023963 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:3023963 | lifeskim:mentions | umls-concept:C0004421 | lld:lifeskim |
| pubmed-article:3023963 | lifeskim:mentions | umls-concept:C0272138 | lld:lifeskim |
| pubmed-article:3023963 | lifeskim:mentions | umls-concept:C1158728 | lld:lifeskim |
| pubmed-article:3023963 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:3023963 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:3023963 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:3023963 | lifeskim:mentions | umls-concept:C1523987 | lld:lifeskim |
| pubmed-article:3023963 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:3023963 | pubmed:dateCreated | 1986-12-22 | lld:pubmed |
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| pubmed-article:3023963 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3023963 | pubmed:abstractText | Avian leukosis virus-induced erythroblastosis results from the specific interruption of the host oncogene, c-erbB, by the insertion of an intact provirus. This insertion results in the expression of two size classes (3.6 and 7.0 kilobases [kb]) of truncated c-erbB transcripts which are initiated in the 5' long terminal repeat of the integrated provirus. Through sequence analysis of erbB cDNA clones we have previously shown that the 3.6-kb activated erbB mRNA contains portions of viral gag and env genes fused to c-erbB sequences (T.W. Nilsen, P.A. Maroney, R.G. Goodwin, F.M. Rottman, L.B. Crittenden, M.A. Raines, and H.-J. Kung, Cell 41:719-726, 1985). In this report we show that the 7-kb mRNA differs from the shorter activated c-erbB mRNA in the length of its 3' untranslated sequence such that the longer mRNA has an extremely long (4.3 kb) 3' untranslated sequence. Additionally, we demonstrate that activated c-erbB mRNA precursors can be processed by alternative splicing to yield mRNAs with viral gag sequences fused directly to c-erbB sequences. Finally, blot hybridization evidence suggests that the two size classes of activated c-erbB mRNA in erythroblastic tissue represent truncated versions of the two c-erbB mRNAs present in normal tissue. | lld:pubmed |
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| pubmed-article:3023963 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3023963 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3023963 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3023963 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3023963 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:3023963 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:3023963 | pubmed:author | pubmed-author:KungH JHJ | lld:pubmed |
| pubmed-article:3023963 | pubmed:author | pubmed-author:RottmanF MFM | lld:pubmed |
| pubmed-article:3023963 | pubmed:author | pubmed-author:MaroneyP APA | lld:pubmed |
| pubmed-article:3023963 | pubmed:author | pubmed-author:NilsenT WTW | lld:pubmed |
| pubmed-article:3023963 | pubmed:author | pubmed-author:GoodwinR GRG | lld:pubmed |
| pubmed-article:3023963 | pubmed:author | pubmed-author:CallaghanTT | lld:pubmed |
| pubmed-article:3023963 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3023963 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:3023963 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3023963 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3023963 | pubmed:pagination | 3128-33 | lld:pubmed |
| pubmed-article:3023963 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3023963 | pubmed:meshHeading | pubmed-meshheading:3023963-... | lld:pubmed |
| pubmed-article:3023963 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3023963 | pubmed:articleTitle | c-erbB activation in avian leukosis virus-induced erythroblastosis: multiple epidermal growth factor receptor mRNAs are generated by alternative RNA processing. | lld:pubmed |
| pubmed-article:3023963 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3023963 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3023963 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:3023963 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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