pubmed-article:3022680 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:3022680 | lifeskim:mentions | umls-concept:C0243139 | lld:lifeskim |
pubmed-article:3022680 | lifeskim:mentions | umls-concept:C0025979 | lld:lifeskim |
pubmed-article:3022680 | lifeskim:mentions | umls-concept:C0017982 | lld:lifeskim |
pubmed-article:3022680 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
pubmed-article:3022680 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
pubmed-article:3022680 | pubmed:issue | 3-4 | lld:pubmed |
pubmed-article:3022680 | pubmed:dateCreated | 1986-11-24 | lld:pubmed |
pubmed-article:3022680 | pubmed:abstractText | Two and a half hours after infection with a high dose of different strains of HSV-1 which induce rounding of cells, breakdown of actin containing microfilaments can be observed. At the periphery of the cell, actin containing knob-like protuberances were visible. Later on, actin seems to be located exclusively on the surface of cells. Observations were done by immunofluorescence microscopy, scanning electron-microscopy and immunoperoxidase staining of ultrathin sections. The envelope of HSV appears to be stained by anti-actin. Strain IES produces rounding of cells at a high dose of infection before fusion proceeds at 37 degrees C. Similar alterations were not observed with the fusing strains MP and HFEM. Incubation of infected cells at 39 degrees C revealed strain dependent differences of the fusion activity. At 41 degrees C no "fusion from within" of cells but only rounding was detectable. Application of tunicamycin resulted in complete inhibition of fusion by all strains. The fusion activity of some strains of HSV-1 (ANG, HFEM, and MP) was not inhibited by addition of 2-deoxy-D-glucose and 2-fluoro-deoxy-D-glucose. A variant from strain MP could be isolated, which is sensitive to the effects of 2-deoxy-D-glucose. Inhibitors of processing of glycoproteins did not affect fusion of cells. | lld:pubmed |
pubmed-article:3022680 | pubmed:language | eng | lld:pubmed |
pubmed-article:3022680 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3022680 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:3022680 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3022680 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:3022680 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3022680 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:3022680 | pubmed:issn | 0304-8608 | lld:pubmed |
pubmed-article:3022680 | pubmed:author | pubmed-author:FalkeDD | lld:pubmed |
pubmed-article:3022680 | pubmed:author | pubmed-author:MüllerSS | lld:pubmed |
pubmed-article:3022680 | pubmed:author | pubmed-author:DienesH PHP | lld:pubmed |
pubmed-article:3022680 | pubmed:author | pubmed-author:HeegUU | lld:pubmed |
pubmed-article:3022680 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:3022680 | pubmed:volume | 91 | lld:pubmed |
pubmed-article:3022680 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:3022680 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:3022680 | pubmed:pagination | 257-70 | lld:pubmed |
pubmed-article:3022680 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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pubmed-article:3022680 | pubmed:year | 1986 | lld:pubmed |
pubmed-article:3022680 | pubmed:articleTitle | Involvement of actin-containing microfilaments in HSV-induced cytopathology and the influence of inhibitors of glycosylation. | lld:pubmed |
pubmed-article:3022680 | pubmed:publicationType | Journal Article | lld:pubmed |
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