| pubmed-article:3021865 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3021865 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:3021865 | lifeskim:mentions | umls-concept:C0080103 | lld:lifeskim |
| pubmed-article:3021865 | lifeskim:mentions | umls-concept:C0026473 | lld:lifeskim |
| pubmed-article:3021865 | lifeskim:mentions | umls-concept:C1383501 | lld:lifeskim |
| pubmed-article:3021865 | lifeskim:mentions | umls-concept:C0021740 | lld:lifeskim |
| pubmed-article:3021865 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:3021865 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:3021865 | pubmed:dateCreated | 1986-12-8 | lld:pubmed |
| pubmed-article:3021865 | pubmed:abstractText | Oxygen metabolism and calcium ion (Ca++) handling in blood monocytes were greatly affected by treatment with recombinant gamma interferon (rIFN-gamma). Incubating the monocytes with rIFN-gamma resulted in increased basal production of superoxide anion, as well as a significantly enhanced respiratory burst in response to concanavalin A (Con A). A concomitant increase in microbicidal activity against Listeria monocytogenes was observed, and cell membrane permeability to Ca++ was enhanced by treatment with rIFN-gamma. Con A stimulation was also associated with acute rises in cytosolic-free calcium, and these calcium transients were greatly augmented in cells pretreated with rIFN-gamma. The enhanced respiratory burst and the increased calcium transients were completely neutralized by a monoclonal antibody to rIFN-gamma. Furthermore, enhancement of the respiratory burst and calcium transients occurred in a parallel dose-response range for rIFN-gamma. Blocking the intracellular release of calcium into cytosol by TMB-8 abrogated the capacity of rIFN-gamma to enhance the monocyte respiratory burst. Thus, not only was rIFN-gamma treatment of monocytes associated with altered calcium metabolism, but calcium from intracellular pools was essential to the expression of this activated state during Con A stimulation. | lld:pubmed |
| pubmed-article:3021865 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3021865 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3021865 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3021865 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:3021865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3021865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3021865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3021865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3021865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3021865 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3021865 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:3021865 | pubmed:issn | 0022-1899 | lld:pubmed |
| pubmed-article:3021865 | pubmed:author | pubmed-author:PenningtonJ... | lld:pubmed |
| pubmed-article:3021865 | pubmed:author | pubmed-author:KemmerichBB | lld:pubmed |
| pubmed-article:3021865 | pubmed:author | pubmed-author:SmallG JGJ | lld:pubmed |
| pubmed-article:3021865 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3021865 | pubmed:volume | 154 | lld:pubmed |
| pubmed-article:3021865 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3021865 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3021865 | pubmed:pagination | 770-7 | lld:pubmed |
| pubmed-article:3021865 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:3021865 | pubmed:meshHeading | pubmed-meshheading:3021865-... | lld:pubmed |
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| pubmed-article:3021865 | pubmed:meshHeading | pubmed-meshheading:3021865-... | lld:pubmed |
| pubmed-article:3021865 | pubmed:meshHeading | pubmed-meshheading:3021865-... | lld:pubmed |
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| pubmed-article:3021865 | pubmed:meshHeading | pubmed-meshheading:3021865-... | lld:pubmed |
| pubmed-article:3021865 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3021865 | pubmed:articleTitle | Relation of cytosolic calcium to the microbicidal activation of blood monocytes by recombinant gamma interferon. | lld:pubmed |
| pubmed-article:3021865 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3021865 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3021865 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3021865 | lld:pubmed |
