| pubmed-article:3018396 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3018396 | lifeskim:mentions | umls-concept:C0031809 | lld:lifeskim |
| pubmed-article:3018396 | lifeskim:mentions | umls-concept:C0015133 | lld:lifeskim |
| pubmed-article:3018396 | lifeskim:mentions | umls-concept:C0005508 | lld:lifeskim |
| pubmed-article:3018396 | lifeskim:mentions | umls-concept:C1979963 | lld:lifeskim |
| pubmed-article:3018396 | lifeskim:mentions | umls-concept:C0332257 | lld:lifeskim |
| pubmed-article:3018396 | lifeskim:mentions | umls-concept:C2003903 | lld:lifeskim |
| pubmed-article:3018396 | lifeskim:mentions | umls-concept:C0201734 | lld:lifeskim |
| pubmed-article:3018396 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3018396 | pubmed:dateCreated | 1986-10-23 | lld:pubmed |
| pubmed-article:3018396 | pubmed:abstractText | The pharmacokinetics of intravenous etoposide (50-150 mg m-2) have been studied in 17 patients. Bioavailability studies on either the capsule or intravenous (i.v.) formulation were performed in 13 patients, 7 of whom received both oral formulations given in the dose range 50-250 mg m-2. After i.v. administration the mean +/- SD half-lives were t1/2 alpha 0.62 +/- 1.01 h and t1/2 beta 6.04 +/- 2.5 h. The bioavailability of etoposide was extremely variable: for the capsule it was 38 +/- 14% (range 10-55) and for the i.v. formulation it was 53 +/- 25% (range 31-88). The i.v. formulation was not significantly better than the capsule. The results confirm the low and variable bioavailability of oral etoposide. | lld:pubmed |
| pubmed-article:3018396 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3018396 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3018396 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3018396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3018396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3018396 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3018396 | pubmed:issn | 0736-0118 | lld:pubmed |
| pubmed-article:3018396 | pubmed:author | pubmed-author:SoukopMM | lld:pubmed |
| pubmed-article:3018396 | pubmed:author | pubmed-author:CunninghamDD | lld:pubmed |
| pubmed-article:3018396 | pubmed:author | pubmed-author:StuartJ FJF | lld:pubmed |
| pubmed-article:3018396 | pubmed:author | pubmed-author:CummingsJJ | lld:pubmed |
| pubmed-article:3018396 | pubmed:author | pubmed-author:ForrestG JGJ | lld:pubmed |
| pubmed-article:3018396 | pubmed:author | pubmed-author:McTaggartLL | lld:pubmed |
| pubmed-article:3018396 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3018396 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:3018396 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3018396 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3018396 | pubmed:pagination | 95-9 | lld:pubmed |
| pubmed-article:3018396 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3018396 | pubmed:meshHeading | pubmed-meshheading:3018396-... | lld:pubmed |
| pubmed-article:3018396 | pubmed:meshHeading | pubmed-meshheading:3018396-... | lld:pubmed |
| pubmed-article:3018396 | pubmed:meshHeading | pubmed-meshheading:3018396-... | lld:pubmed |
| pubmed-article:3018396 | pubmed:meshHeading | pubmed-meshheading:3018396-... | lld:pubmed |
| pubmed-article:3018396 | pubmed:meshHeading | pubmed-meshheading:3018396-... | lld:pubmed |
| pubmed-article:3018396 | pubmed:meshHeading | pubmed-meshheading:3018396-... | lld:pubmed |
| pubmed-article:3018396 | pubmed:meshHeading | pubmed-meshheading:3018396-... | lld:pubmed |
| pubmed-article:3018396 | pubmed:meshHeading | pubmed-meshheading:3018396-... | lld:pubmed |
| pubmed-article:3018396 | pubmed:meshHeading | pubmed-meshheading:3018396-... | lld:pubmed |
| pubmed-article:3018396 | pubmed:meshHeading | pubmed-meshheading:3018396-... | lld:pubmed |
| pubmed-article:3018396 | pubmed:meshHeading | pubmed-meshheading:3018396-... | lld:pubmed |
| pubmed-article:3018396 | pubmed:meshHeading | pubmed-meshheading:3018396-... | lld:pubmed |
| pubmed-article:3018396 | pubmed:meshHeading | pubmed-meshheading:3018396-... | lld:pubmed |
| pubmed-article:3018396 | pubmed:meshHeading | pubmed-meshheading:3018396-... | lld:pubmed |
| pubmed-article:3018396 | pubmed:meshHeading | pubmed-meshheading:3018396-... | lld:pubmed |
| pubmed-article:3018396 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3018396 | pubmed:articleTitle | Etoposide: a pharmacokinetic profile including an assessment of bioavailability. | lld:pubmed |
| pubmed-article:3018396 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3018396 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3018396 | lld:pubmed |
