| pubmed-article:3011845 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3011845 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:3011845 | lifeskim:mentions | umls-concept:C0010744 | lld:lifeskim |
| pubmed-article:3011845 | lifeskim:mentions | umls-concept:C0016223 | lld:lifeskim |
| pubmed-article:3011845 | lifeskim:mentions | umls-concept:C0018203 | lld:lifeskim |
| pubmed-article:3011845 | lifeskim:mentions | umls-concept:C0085416 | lld:lifeskim |
| pubmed-article:3011845 | lifeskim:mentions | umls-concept:C0008902 | lld:lifeskim |
| pubmed-article:3011845 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:3011845 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3011845 | pubmed:dateCreated | 1986-6-27 | lld:pubmed |
| pubmed-article:3011845 | pubmed:abstractText | Twenty-five patients suffering from chronic granulomatous disease (CGD) and their families were investigated. Defects in the superoxide generating system were characterized at the level of the heme-containing cytochrome b and of the FAD-containing flavoprotein, both localized in the plasma membrane of granulocytes. It was confirmed that in most of the typical cases (18 of 22), the complete inability of superoxide generation was associated with the absence of detectable cytochrome b. Mothers but not fathers of such male patients were characterized by a diminished content of cytochrome b, confirming that the affected gene is localized on the X chromosome. In contrast, the granulocytes of four other typical patients (two female and two male) contained normal amounts of cytochrome b, whereas oxidative activity was absent. Since no abnormality of oxidative activity as well as of cytochrome b was found in granulocytes of the mothers and fathers of these patients, an autosomal recessive mode of inheritance of the disease is probable. The flavoprotein deficiency found in the granulocytes of four male patients was always associated with an absence of detectable cytochrome b. This could indicate a structural relationship between flavoprotein and cytochrome b (e.g., a flavocytochrome). Three further patients with mild X-linked CGD contrasted with the patients with severe or classic X-linked disease; the oxidative activity of their phagocytes was diminished but not absent, and the cytochrome b present, albeit in small amounts. | lld:pubmed |
| pubmed-article:3011845 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3011845 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3011845 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3011845 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3011845 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3011845 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3011845 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3011845 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3011845 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3011845 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:3011845 | pubmed:issn | 0271-9142 | lld:pubmed |
| pubmed-article:3011845 | pubmed:author | pubmed-author:GriscelliCC | lld:pubmed |
| pubmed-article:3011845 | pubmed:author | pubmed-author:FischerAA | lld:pubmed |
| pubmed-article:3011845 | pubmed:author | pubmed-author:VilmerEE | lld:pubmed |
| pubmed-article:3011845 | pubmed:author | pubmed-author:SegerR ARA | lld:pubmed |
| pubmed-article:3011845 | pubmed:author | pubmed-author:BohlerM CMC | lld:pubmed |
| pubmed-article:3011845 | pubmed:author | pubmed-author:PeatW EWE | lld:pubmed |
| pubmed-article:3011845 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3011845 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:3011845 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3011845 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3011845 | pubmed:pagination | 136-45 | lld:pubmed |
| pubmed-article:3011845 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:3011845 | pubmed:meshHeading | pubmed-meshheading:3011845-... | lld:pubmed |
| pubmed-article:3011845 | pubmed:meshHeading | pubmed-meshheading:3011845-... | lld:pubmed |
| pubmed-article:3011845 | pubmed:meshHeading | pubmed-meshheading:3011845-... | lld:pubmed |
| pubmed-article:3011845 | pubmed:meshHeading | pubmed-meshheading:3011845-... | lld:pubmed |
| pubmed-article:3011845 | pubmed:meshHeading | pubmed-meshheading:3011845-... | lld:pubmed |
| pubmed-article:3011845 | pubmed:meshHeading | pubmed-meshheading:3011845-... | lld:pubmed |
| pubmed-article:3011845 | pubmed:meshHeading | pubmed-meshheading:3011845-... | lld:pubmed |
| pubmed-article:3011845 | pubmed:meshHeading | pubmed-meshheading:3011845-... | lld:pubmed |
| pubmed-article:3011845 | pubmed:meshHeading | pubmed-meshheading:3011845-... | lld:pubmed |
| pubmed-article:3011845 | pubmed:meshHeading | pubmed-meshheading:3011845-... | lld:pubmed |
| pubmed-article:3011845 | pubmed:meshHeading | pubmed-meshheading:3011845-... | lld:pubmed |
| pubmed-article:3011845 | pubmed:meshHeading | pubmed-meshheading:3011845-... | lld:pubmed |
| pubmed-article:3011845 | pubmed:meshHeading | pubmed-meshheading:3011845-... | lld:pubmed |
| pubmed-article:3011845 | pubmed:meshHeading | pubmed-meshheading:3011845-... | lld:pubmed |
| pubmed-article:3011845 | pubmed:meshHeading | pubmed-meshheading:3011845-... | lld:pubmed |
| pubmed-article:3011845 | pubmed:meshHeading | pubmed-meshheading:3011845-... | lld:pubmed |
| pubmed-article:3011845 | pubmed:meshHeading | pubmed-meshheading:3011845-... | lld:pubmed |
| pubmed-article:3011845 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3011845 | pubmed:articleTitle | A study of 25 patients with chronic granulomatous disease: a new classification by correlating respiratory burst, cytochrome b, and flavoprotein. | lld:pubmed |
| pubmed-article:3011845 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3011845 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:3011845 | pubmed:publicationType | Case Reports | lld:pubmed |
| pubmed-article:3011845 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3011845 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3011845 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3011845 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3011845 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3011845 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3011845 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3011845 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3011845 | lld:pubmed |
