| pubmed-article:3008940 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3008940 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:3008940 | lifeskim:mentions | umls-concept:C0020663 | lld:lifeskim |
| pubmed-article:3008940 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:3008940 | lifeskim:mentions | umls-concept:C0038869 | lld:lifeskim |
| pubmed-article:3008940 | lifeskim:mentions | umls-concept:C0030532 | lld:lifeskim |
| pubmed-article:3008940 | lifeskim:mentions | umls-concept:C0028351 | lld:lifeskim |
| pubmed-article:3008940 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:3008940 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:3008940 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:3008940 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:3008940 | pubmed:dateCreated | 1986-6-13 | lld:pubmed |
| pubmed-article:3008940 | pubmed:abstractText | In an attempt to determine the basis for apparently conflicting reports of the effects of noradrenaline (NA) on the neurohypophyseal system and its effects on the parvocellular periventricular region of the paraventricular nucleus (PVN), recordings were made from the neurons in the supraoptic nucleus (SON) and the periventricular region in the mouse hypothalamic slice preparation. Of 47 SON neurons, 43 (91%) were excited and two (4%) were inhibited by NA. Seven SON neurons increased the firing rate with increase of NA concentration (10(-7)-10(-4) M). Both the alpha 1-agonists phenylephrine and methoxamine also increased the activity of all SON neurons tested whereas application of the alpha 2-agonist clonidine and the beta-agonist isoproterenol had weak and inconsistent effects. While the alpha 2-antagonist yohimbine had no consistent influence, the alpha 1-antagonist prazosin blocked or reversed the effects of NA. Another group of 37 neurons in the periventricular region of the PVN was also tested; 13 (35%) were excited and 22 (59%) inhibited by application of NA (10(-5) M). When tested with phenylephrine or methoxamine, 6 of the 7 neurons were excited and one inhibited but all the 4 neurons tested were excited by isoproterenol. Clonidine strongly depressed the activity of all 12 neurons tested. The NA-induced excitatory effects were suppressed or reversed by pre-application of prazosin and the beta-antagonist propranolol while the inhibitory ones were suppressed or reversed by yohimbine. Synaptic blockade did not affect the excitatory responses of SON cells to NA nor the inhibitory responses of periventricular neurons to NA or clonidine. We conclude that SON neurons receive adrenergic excitatory effects mainly through alpha 1-receptors. The periventricular neurons receive the excitatory effects through alpha 1- or beta-receptors and receive the inhibitory effects through alpha 2-receptors. | lld:pubmed |
| pubmed-article:3008940 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3008940 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3008940 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3008940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3008940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3008940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3008940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3008940 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3008940 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:3008940 | pubmed:issn | 0006-8993 | lld:pubmed |
| pubmed-article:3008940 | pubmed:author | pubmed-author:YamashitaHH | lld:pubmed |
| pubmed-article:3008940 | pubmed:author | pubmed-author:DyballR ERE | lld:pubmed |
| pubmed-article:3008940 | pubmed:author | pubmed-author:InenagaKK | lld:pubmed |
| pubmed-article:3008940 | pubmed:author | pubmed-author:OkuyaSS | lld:pubmed |
| pubmed-article:3008940 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3008940 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:3008940 | pubmed:volume | 369 | lld:pubmed |
| pubmed-article:3008940 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3008940 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3008940 | pubmed:pagination | 37-47 | lld:pubmed |
| pubmed-article:3008940 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3008940 | pubmed:meshHeading | pubmed-meshheading:3008940-... | lld:pubmed |
| pubmed-article:3008940 | pubmed:meshHeading | pubmed-meshheading:3008940-... | lld:pubmed |
| pubmed-article:3008940 | pubmed:meshHeading | pubmed-meshheading:3008940-... | lld:pubmed |
| pubmed-article:3008940 | pubmed:meshHeading | pubmed-meshheading:3008940-... | lld:pubmed |
| pubmed-article:3008940 | pubmed:meshHeading | pubmed-meshheading:3008940-... | lld:pubmed |
| pubmed-article:3008940 | pubmed:meshHeading | pubmed-meshheading:3008940-... | lld:pubmed |
| pubmed-article:3008940 | pubmed:meshHeading | pubmed-meshheading:3008940-... | lld:pubmed |
| pubmed-article:3008940 | pubmed:meshHeading | pubmed-meshheading:3008940-... | lld:pubmed |
| pubmed-article:3008940 | pubmed:meshHeading | pubmed-meshheading:3008940-... | lld:pubmed |
| pubmed-article:3008940 | pubmed:meshHeading | pubmed-meshheading:3008940-... | lld:pubmed |
| pubmed-article:3008940 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3008940 | pubmed:articleTitle | Characterization of hypothalamic noradrenaline receptors in the supraoptic nucleus and periventricular region of the paraventricular nucleus of mice in vitro. | lld:pubmed |
| pubmed-article:3008940 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3008940 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:3008940 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
