| pubmed-article:3008085 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3008085 | lifeskim:mentions | umls-concept:C0012863 | lld:lifeskim |
| pubmed-article:3008085 | lifeskim:mentions | umls-concept:C0028458 | lld:lifeskim |
| pubmed-article:3008085 | lifeskim:mentions | umls-concept:C1514668 | lld:lifeskim |
| pubmed-article:3008085 | lifeskim:mentions | umls-concept:C1514665 | lld:lifeskim |
| pubmed-article:3008085 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:3008085 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:3008085 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:3008085 | pubmed:dateCreated | 1986-4-25 | lld:pubmed |
| pubmed-article:3008085 | pubmed:abstractText | The role of DNA topoisomerases in eucaryotic class III gene transcription in vitro has been studied through the use of inhibitory drugs and antisera to DNA topoisomerases I and II. The DNA topoisomerase II inhibitors, novobiocin and coumermycin AI, were found to inhibit transcription of cloned 5S and tRNA genes. Novobiocin acts by interfering with an ATP-requiring step in the pathway to stable preinitiation complex formation. However, it is unlikely that this step reflects the enzymatic action of DNA topoisomerase II since a specific inhibitor of this enzyme (VM-26) and anti-DNA topoisomerase II antibodies fail to inhibit transcription under conditions where topoisomerase II enzymatic activity is inhibited. Similarly, a specific inhibitor of DNA topoisomerase I (camptothecin) and anti-DNA topoisomerase I antibodies fail to inhibit class III gene transcription. These results argue against a role for either DNA topoisomerase in 5S or tRNA gene transcription in vitro. | lld:pubmed |
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| pubmed-article:3008085 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:3008085 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3008085 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3008085 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:3008085 | pubmed:issn | 0305-1048 | lld:pubmed |
| pubmed-article:3008085 | pubmed:author | pubmed-author:GottesfeldJ... | lld:pubmed |
| pubmed-article:3008085 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3008085 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:3008085 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:3008085 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3008085 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3008085 | pubmed:pagination | 2075-88 | lld:pubmed |
| pubmed-article:3008085 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:3008085 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3008085 | pubmed:articleTitle | Novobiocin inhibits RNA polymerase III transcription in vitro by a mechanism distinct from DNA topoisomerase II. | lld:pubmed |
| pubmed-article:3008085 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3008085 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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