| pubmed-article:3005566 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3005566 | lifeskim:mentions | umls-concept:C0003451 | lld:lifeskim |
| pubmed-article:3005566 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:3005566 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:3005566 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:3005566 | lifeskim:mentions | umls-concept:C0626377 | lld:lifeskim |
| pubmed-article:3005566 | lifeskim:mentions | umls-concept:C0048975 | lld:lifeskim |
| pubmed-article:3005566 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3005566 | pubmed:dateCreated | 1986-3-28 | lld:pubmed |
| pubmed-article:3005566 | pubmed:abstractText | (E)-5-(2-Bromovinyl)uracil (BVU) and (E)-5-(2-bromovinyl)uridine (BVRU) were synthesized starting from 5-formyluracil via (E)-5-(2-carboxyvinyl)uracil or starting from 5-iodouridine via (E)-5-(2-carbomethoxyvinyl)uridine and (E)-5-(2-carboxyvinyl)uridine, respectively. Depending on the choice of the cell system, BVU and BVRU exhibited a marked activity against herpes simplex virus type 1 (HSV-1) in vitro. Although BVU and BVRU were less potent than the reference compound (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU), their antiviral activity spectrum was remarkably similar to that of BVDU. The latter findings suggest that BVU and BVRU are metabolically converted to BVDU or a phosphorylated product thereof. In vivo, BVU protected mice against a lethal disseminated HSV-1 infection. | lld:pubmed |
| pubmed-article:3005566 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3005566 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3005566 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3005566 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3005566 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3005566 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3005566 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3005566 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3005566 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3005566 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3005566 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3005566 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:3005566 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:3005566 | pubmed:author | pubmed-author:De ClercqEE | lld:pubmed |
| pubmed-article:3005566 | pubmed:author | pubmed-author:DesgrangesCC | lld:pubmed |
| pubmed-article:3005566 | pubmed:author | pubmed-author:McLeanM JMJ | lld:pubmed |
| pubmed-article:3005566 | pubmed:author | pubmed-author:JonesA SAS | lld:pubmed |
| pubmed-article:3005566 | pubmed:author | pubmed-author:WalkerR TRT | lld:pubmed |
| pubmed-article:3005566 | pubmed:author | pubmed-author:SimI SIS | lld:pubmed |
| pubmed-article:3005566 | pubmed:author | pubmed-author:HerdewijnPP | lld:pubmed |
| pubmed-article:3005566 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3005566 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:3005566 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3005566 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3005566 | pubmed:pagination | 213-7 | lld:pubmed |
| pubmed-article:3005566 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3005566 | pubmed:meshHeading | pubmed-meshheading:3005566-... | lld:pubmed |
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| pubmed-article:3005566 | pubmed:meshHeading | pubmed-meshheading:3005566-... | lld:pubmed |
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| pubmed-article:3005566 | pubmed:meshHeading | pubmed-meshheading:3005566-... | lld:pubmed |
| pubmed-article:3005566 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3005566 | pubmed:articleTitle | Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine. | lld:pubmed |
| pubmed-article:3005566 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3005566 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:3005566 | lld:chembl |
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