pubmed-article:3001361 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:3001361 | lifeskim:mentions | umls-concept:C0016720 | lld:lifeskim |
pubmed-article:3001361 | lifeskim:mentions | umls-concept:C0042776 | lld:lifeskim |
pubmed-article:3001361 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
pubmed-article:3001361 | lifeskim:mentions | umls-concept:C0026179 | lld:lifeskim |
pubmed-article:3001361 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
pubmed-article:3001361 | lifeskim:mentions | umls-concept:C0038002 | lld:lifeskim |
pubmed-article:3001361 | lifeskim:mentions | umls-concept:C0080194 | lld:lifeskim |
pubmed-article:3001361 | lifeskim:mentions | umls-concept:C0085732 | lld:lifeskim |
pubmed-article:3001361 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
pubmed-article:3001361 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
pubmed-article:3001361 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
pubmed-article:3001361 | pubmed:issue | 1 | lld:pubmed |
pubmed-article:3001361 | pubmed:dateCreated | 1986-1-24 | lld:pubmed |
pubmed-article:3001361 | pubmed:abstractText | Friend murine leukemia helper viruses (F-MuLV) 57 and B3 were indistinguishable by genomic structural analyses with RNase T1-resistant oligonucleotide fingerprinting and by antigenic reactivity with a panel of 31 monoclonal antibodies directed against murine leukemia viruses. Nevertheless, F-MuLV 57 and B3 had strikingly different virulences. Approximately 2 months after inoculation, IRW and NFS/N mice inoculated as newborns with F-MuLV 57 had gross splenomegaly caused by erythroid proliferation. In contrast, an equivalent dose of F-MuLV B3 induced spleen or lymph node enlargement 4 to 13 months after inoculation. Although most cases of spleen enlargement in F-MuLV B3-inoculated mice were due to erythroid proliferation, lymphoid or myeloid proliferation was also frequently observed. The replication of both F-MuLV 57 and B3 was equally efficient, and both viruses generated recombinant dual-tropic mink cell focus-forming (MCF) viruses with the same kinetics and efficiency. Moreover, MCF viruses induced by F-MuLV 57 and B3 had the same antigenic patterns. Therefore, the ability of F-MuLV to induce early splenomegaly did not correlate with the generation of recombinant MCF viruses. | lld:pubmed |
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pubmed-article:3001361 | pubmed:language | eng | lld:pubmed |
pubmed-article:3001361 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3001361 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:3001361 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:3001361 | pubmed:month | Jan | lld:pubmed |
pubmed-article:3001361 | pubmed:issn | 0022-538X | lld:pubmed |
pubmed-article:3001361 | pubmed:author | pubmed-author:EvansLL | lld:pubmed |
pubmed-article:3001361 | pubmed:author | pubmed-author:ChesebroBB | lld:pubmed |
pubmed-article:3001361 | pubmed:author | pubmed-author:NishioJJ | lld:pubmed |
pubmed-article:3001361 | pubmed:author | pubmed-author:WehrlyKK | lld:pubmed |
pubmed-article:3001361 | pubmed:author | pubmed-author:SitbonMM | lld:pubmed |
pubmed-article:3001361 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:3001361 | pubmed:volume | 57 | lld:pubmed |
pubmed-article:3001361 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:3001361 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:3001361 | pubmed:pagination | 389-93 | lld:pubmed |
pubmed-article:3001361 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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pubmed-article:3001361 | pubmed:year | 1986 | lld:pubmed |
pubmed-article:3001361 | pubmed:articleTitle | Analysis of two strains of Friend murine leukemia viruses differing in ability to induce early splenomegaly: lack of relationship with generation of recombinant mink cell focus-forming viruses. | lld:pubmed |
pubmed-article:3001361 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:3001361 | pubmed:publicationType | Comparative Study | lld:pubmed |
pubmed-article:3001361 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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