| pubmed-article:3000728 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3000728 | lifeskim:mentions | umls-concept:C0221920 | lld:lifeskim |
| pubmed-article:3000728 | lifeskim:mentions | umls-concept:C0014912 | lld:lifeskim |
| pubmed-article:3000728 | lifeskim:mentions | umls-concept:C1512505 | lld:lifeskim |
| pubmed-article:3000728 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:3000728 | lifeskim:mentions | umls-concept:C1305923 | lld:lifeskim |
| pubmed-article:3000728 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:3000728 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:3000728 | pubmed:dateCreated | 1986-1-30 | lld:pubmed |
| pubmed-article:3000728 | pubmed:abstractText | MCF-7 human breast cancer cells release polypeptides related to insulin-like growth factor-I (IGF-I) and epidermal growth factor (EGF) into serum-free culture medium (CM). Treatment of MCF-7 cells with 17 beta-estradiol, which is required in vivo for MCF-7 tumor growth in the nude mouse and stimulates the MCF-7 growth rate in vitro, resulted in selectively enhanced growth factor activities in CM. Autostimulatory growth-promoting activity was elevated at least 2-fold, and EGF-like polypeptides were elevated 5-fold but IGF-I immunoreactivity was not elevated. Several species of estrogen-induced receptor-reactive EGF-like polypeptides, suggestive of high molecular weight transforming growth factor alpha, were detected after gel exclusion chromatography of CM extracted with 1 M acetic acid. A 30,000 mol wt peak of EGF receptor competing activity comigrated with a peak of autostimulatory and fibroblast-transforming activity. It is possible that estradiol stimulation of MCF-7 growth and/or tumor formation may depend on induction of EGF-related polypeptide growth factors. EGF-I- and EGF-related polypeptides may act together as autocrine or paracrine growth factors in breast cancer. | lld:pubmed |
| pubmed-article:3000728 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3000728 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3000728 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:3000728 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3000728 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3000728 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:3000728 | pubmed:issn | 0013-7227 | lld:pubmed |
| pubmed-article:3000728 | pubmed:author | pubmed-author:LippmanM EME | lld:pubmed |
| pubmed-article:3000728 | pubmed:author | pubmed-author:DicksonR BRB | lld:pubmed |
| pubmed-article:3000728 | pubmed:author | pubmed-author:SpencerE MEM | lld:pubmed |
| pubmed-article:3000728 | pubmed:author | pubmed-author:HuffK KKK | lld:pubmed |
| pubmed-article:3000728 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3000728 | pubmed:volume | 118 | lld:pubmed |
| pubmed-article:3000728 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3000728 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3000728 | pubmed:pagination | 138-42 | lld:pubmed |
| pubmed-article:3000728 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:3000728 | pubmed:meshHeading | pubmed-meshheading:3000728-... | lld:pubmed |
| pubmed-article:3000728 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3000728 | pubmed:articleTitle | Induction of epidermal growth factor-related polypeptides by 17 beta-estradiol in MCF-7 human breast cancer cells. | lld:pubmed |
| pubmed-article:3000728 | pubmed:publicationType | Journal Article | lld:pubmed |
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