| pubmed-article:2999772 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2999772 | lifeskim:mentions | umls-concept:C0015576 | lld:lifeskim |
| pubmed-article:2999772 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:2999772 | lifeskim:mentions | umls-concept:C1257740 | lld:lifeskim |
| pubmed-article:2999772 | lifeskim:mentions | umls-concept:C0005919 | lld:lifeskim |
| pubmed-article:2999772 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:2999772 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:2999772 | pubmed:dateCreated | 1985-12-24 | lld:pubmed |
| pubmed-article:2999772 | pubmed:abstractText | Gastrin-releasing peptide (GRP) labeled with 125I at tyrosine-15 (125I-GRP) binds to intact quiescent Swiss 3T3 cells in a specific and saturable manner. Scatchard analysis indicates the presence of a single class of high-affinity binding sites of Kd = 0.5 X 10(-9) M and a value for the number of sites per cell of about 100,000. 125I-GRP binding was not inhibited by other mitogens for these cells, and cell lines that are mitogenically unresponsive to GRP do not exhibit specific GRP binding. Structure-activity relationships show a close parallel between the ability of a range of GRP-related peptides to both inhibit GRP binding and to stimulate mitogenesis. Further, GRP binding is selectively blocked in a competitive fashion by a novel bombesin antagonist, [D-Arg1, D-Pro2, D-Trp7,9, Leu11] substance P. In addition, this compound selectively inhibits GRP and bombesin-induced mitogenesis. These results demonstrate that the mitogenic response of Swiss 3T3 cells to peptides of the bombesin family is mediated by a class of receptors distinct from those of other mitogens for these cells. | lld:pubmed |
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| pubmed-article:2999772 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2999772 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2999772 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2999772 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:2999772 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:2999772 | pubmed:author | pubmed-author:RozengurtEE | lld:pubmed |
| pubmed-article:2999772 | pubmed:author | pubmed-author:ZacharyII | lld:pubmed |
| pubmed-article:2999772 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2999772 | pubmed:volume | 82 | lld:pubmed |
| pubmed-article:2999772 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2999772 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2999772 | pubmed:pagination | 7616-20 | lld:pubmed |
| pubmed-article:2999772 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2999772 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:2999772 | pubmed:articleTitle | High-affinity receptors for peptides of the bombesin family in Swiss 3T3 cells. | lld:pubmed |
| pubmed-article:2999772 | pubmed:publicationType | Journal Article | lld:pubmed |
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