| pubmed-article:2997615 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2997615 | lifeskim:mentions | umls-concept:C0006413 | lld:lifeskim |
| pubmed-article:2997615 | lifeskim:mentions | umls-concept:C0733511 | lld:lifeskim |
| pubmed-article:2997615 | lifeskim:mentions | umls-concept:C0883208 | lld:lifeskim |
| pubmed-article:2997615 | pubmed:issue | 6038 | lld:pubmed |
| pubmed-article:2997615 | pubmed:dateCreated | 1985-11-22 | lld:pubmed |
| pubmed-article:2997615 | pubmed:abstractText | The pathogenesis of Epstein-Barr (EB) virus-positive Burkitt's lymphoma (BL) appears to involve the combined actions of virus-induced B-cell proliferation, and a rare chromosomal translocation juxtaposing c-myc and immunoglobulin gene loci in a single B cell; holoendemic malarial infection in some way facilitates the oncogenic process. Outgrowth of the EB virus-positive tumour suggests either breakdown or evasion of those immune controls, in particular cytotoxic T-cell responses against the virus-induced lymphocyte-detected membrane antigen LYDMA, which limit virus-infected B-cell numbers in healthy virus carriers. Immunosuppression, such as that which malarial infection may induce, cannot itself be a sufficient explanation in this regard since our studies have identified a number of BL patients who retain detectable LYDMA-specific T-cell surveillance. The present work shows that in many cases of virus-associated BL, the emerging malignant clone is insensitive to such surveillance. Several EB virus-positive BL cell lines, recently established in vitro and expressing the class I histocompatibility locus antigens (HLAs) which restrict cytotoxic T-cell function, were not killed by HLA-matched LYDMA-specific effector populations in assays where the EB virus-positive lymphoblastoid cell line (LCL), derived from normal B cells of the same patient, sustained high levels of lysis. | lld:pubmed |
| pubmed-article:2997615 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2997615 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2997615 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2997615 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2997615 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2997615 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2997615 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2997615 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:2997615 | pubmed:author | pubmed-author:RickinsonA... | lld:pubmed |
| pubmed-article:2997615 | pubmed:author | pubmed-author:RoweMM | lld:pubmed |
| pubmed-article:2997615 | pubmed:author | pubmed-author:RooneyC MCM | lld:pubmed |
| pubmed-article:2997615 | pubmed:author | pubmed-author:WallaceL ELE | lld:pubmed |
| pubmed-article:2997615 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2997615 | pubmed:volume | 317 | lld:pubmed |
| pubmed-article:2997615 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2997615 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2997615 | pubmed:pagination | 629-31 | lld:pubmed |
| pubmed-article:2997615 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:2997615 | pubmed:meshHeading | pubmed-meshheading:2997615-... | lld:pubmed |
| pubmed-article:2997615 | pubmed:meshHeading | pubmed-meshheading:2997615-... | lld:pubmed |
| pubmed-article:2997615 | pubmed:meshHeading | pubmed-meshheading:2997615-... | lld:pubmed |
| pubmed-article:2997615 | pubmed:meshHeading | pubmed-meshheading:2997615-... | lld:pubmed |
| pubmed-article:2997615 | pubmed:meshHeading | pubmed-meshheading:2997615-... | lld:pubmed |
| pubmed-article:2997615 | pubmed:meshHeading | pubmed-meshheading:2997615-... | lld:pubmed |
| pubmed-article:2997615 | pubmed:meshHeading | pubmed-meshheading:2997615-... | lld:pubmed |
| pubmed-article:2997615 | pubmed:meshHeading | pubmed-meshheading:2997615-... | lld:pubmed |
| pubmed-article:2997615 | pubmed:articleTitle | Epstein-Barr virus-positive Burkitt's lymphoma cells not recognized by virus-specific T-cell surveillance. | lld:pubmed |
| pubmed-article:2997615 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2997615 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2997615 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2997615 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2997615 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2997615 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2997615 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2997615 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2997615 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2997615 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2997615 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2997615 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2997615 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2997615 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2997615 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2997615 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2997615 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2997615 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2997615 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2997615 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2997615 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2997615 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2997615 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2997615 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2997615 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2997615 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2997615 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2997615 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2997615 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2997615 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2997615 | lld:pubmed |
