| pubmed-article:2991910 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2991910 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2991910 | lifeskim:mentions | umls-concept:C0006826 | lld:lifeskim |
| pubmed-article:2991910 | lifeskim:mentions | umls-concept:C0021368 | lld:lifeskim |
| pubmed-article:2991910 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
| pubmed-article:2991910 | lifeskim:mentions | umls-concept:C0032458 | lld:lifeskim |
| pubmed-article:2991910 | lifeskim:mentions | umls-concept:C0025513 | lld:lifeskim |
| pubmed-article:2991910 | lifeskim:mentions | umls-concept:C1704666 | lld:lifeskim |
| pubmed-article:2991910 | lifeskim:mentions | umls-concept:C1517892 | lld:lifeskim |
| pubmed-article:2991910 | lifeskim:mentions | umls-concept:C0208973 | lld:lifeskim |
| pubmed-article:2991910 | lifeskim:mentions | umls-concept:C0070750 | lld:lifeskim |
| pubmed-article:2991910 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:2991910 | pubmed:dateCreated | 1985-9-6 | lld:pubmed |
| pubmed-article:2991910 | pubmed:abstractText | Oxidants, such as those generated by metabolically activated phagocytes in inflammation, have been implicated in the metabolic activation of carcinogens, and in this study we demonstrate that the interaction of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene (BP 7,8-dihydrodiol) with phorbol ester-stimulated polymorphonuclear leukocytes (PMNs) results in the generation of both a chemiluminescent intermediate and one that covalently binds to DNA. Cu(II)(3,5-diisopropylsalicylic acid)2 (CuDIPS), a biomimetic superoxide dismutase, and azide, a myeloperoxidase inhibitor, inhibited both of these reactions, indicating a dependency on oxygen-derived oxidants in these hydrocarbon-activation processes. Concordant with the formation of a carcinogen-DNA adduct, the admixture of BP 7,8-dihydrodiol and phorbol ester-stimulated PMNs elicited mutagenesis in Salmonella typhimurium strain TA100. 7,8-Dihydro-BP and BP cis-7,8-dihydrodiol were also mutagenic, whereas derivatives lacking a double bond at the 9,10 position were not. These results demonstrate that oxidants generated by metabolically stimulated PMNs can activate penultimate polycyclic aromatic hydrocarbons to a genotoxic metabolite and further defines a role for inflammation in carcinogenesis. | lld:pubmed |
| pubmed-article:2991910 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2991910 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2991910 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991910 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2991910 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2991910 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:2991910 | pubmed:author | pubmed-author:TrushM AMA | lld:pubmed |
| pubmed-article:2991910 | pubmed:author | pubmed-author:KenslerT WTW | lld:pubmed |
| pubmed-article:2991910 | pubmed:author | pubmed-author:SeedJ LJL | lld:pubmed |
| pubmed-article:2991910 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2991910 | pubmed:volume | 82 | lld:pubmed |
| pubmed-article:2991910 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2991910 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2991910 | pubmed:pagination | 5194-8 | lld:pubmed |
| pubmed-article:2991910 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:2991910 | pubmed:meshHeading | pubmed-meshheading:2991910-... | lld:pubmed |
| pubmed-article:2991910 | pubmed:meshHeading | pubmed-meshheading:2991910-... | lld:pubmed |
| pubmed-article:2991910 | pubmed:meshHeading | pubmed-meshheading:2991910-... | lld:pubmed |
| pubmed-article:2991910 | pubmed:meshHeading | pubmed-meshheading:2991910-... | lld:pubmed |
| pubmed-article:2991910 | pubmed:meshHeading | pubmed-meshheading:2991910-... | lld:pubmed |
| pubmed-article:2991910 | pubmed:meshHeading | pubmed-meshheading:2991910-... | lld:pubmed |
| pubmed-article:2991910 | pubmed:meshHeading | pubmed-meshheading:2991910-... | lld:pubmed |
| pubmed-article:2991910 | pubmed:meshHeading | pubmed-meshheading:2991910-... | lld:pubmed |
| pubmed-article:2991910 | pubmed:meshHeading | pubmed-meshheading:2991910-... | lld:pubmed |
| pubmed-article:2991910 | pubmed:meshHeading | pubmed-meshheading:2991910-... | lld:pubmed |
| pubmed-article:2991910 | pubmed:meshHeading | pubmed-meshheading:2991910-... | lld:pubmed |
| pubmed-article:2991910 | pubmed:meshHeading | pubmed-meshheading:2991910-... | lld:pubmed |
| pubmed-article:2991910 | pubmed:meshHeading | pubmed-meshheading:2991910-... | lld:pubmed |
| pubmed-article:2991910 | pubmed:meshHeading | pubmed-meshheading:2991910-... | lld:pubmed |
| pubmed-article:2991910 | pubmed:meshHeading | pubmed-meshheading:2991910-... | lld:pubmed |
| pubmed-article:2991910 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:2991910 | pubmed:articleTitle | Oxidant-dependent metabolic activation of polycyclic aromatic hydrocarbons by phorbol ester-stimulated human polymorphonuclear leukocytes: possible link between inflammation and cancer. | lld:pubmed |
| pubmed-article:2991910 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2991910 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2991910 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
