| pubmed-article:2990708 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2990708 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:2990708 | lifeskim:mentions | umls-concept:C0013216 | lld:lifeskim |
| pubmed-article:2990708 | lifeskim:mentions | umls-concept:C0684249 | lld:lifeskim |
| pubmed-article:2990708 | lifeskim:mentions | umls-concept:C0205696 | lld:lifeskim |
| pubmed-article:2990708 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:2990708 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:2990708 | pubmed:dateCreated | 1985-9-12 | lld:pubmed |
| pubmed-article:2990708 | pubmed:abstractText | The role of intensive induction chemotherapy in small cell cancer of the lung remains unclear. Twenty-eight newly diagnosed patients with small cell lung cancer were randomized to receive either high-dose or standard-dose cyclophosphamide, vincristine, and semustine in a trial where the dose of induction chemotherapy was the sole treatment variable. Complete responses (CR) were achieved in 57% of patients receiving high-dose therapy as compared to 21% of patients receiving standard-dose therapy (P less than 0.05). There was a higher rate of severe toxicity in the high-dose group (P less than 0.01). The overall median survival was not improved (36 weeks for the high-dose group vs 43 weeks for the standard-dose group); however, the median survival in patients achieving CR was prolonged (92 weeks for the high-dose group vs 50 weeks for the standard-dose group). These effects were most pronounced in patients with extensive disease; a CR after induction was achieved in five of nine patients treated with high doses but not in any of those treated with standard doses (P less than 0.05). A small group of patients appear to benefit by achieving a long-term remission with intensive induction chemotherapy, but this effect may be offset by increased morbidity. | lld:pubmed |
| pubmed-article:2990708 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2990708 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2990708 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2990708 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2990708 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2990708 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2990708 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2990708 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2990708 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2990708 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2990708 | pubmed:issn | 0361-5960 | lld:pubmed |
| pubmed-article:2990708 | pubmed:author | pubmed-author:McKneallyM... | lld:pubmed |
| pubmed-article:2990708 | pubmed:author | pubmed-author:HortonJJ | lld:pubmed |
| pubmed-article:2990708 | pubmed:author | pubmed-author:RuckdeschelJ... | lld:pubmed |
| pubmed-article:2990708 | pubmed:author | pubmed-author:CaradonnaRR | lld:pubmed |
| pubmed-article:2990708 | pubmed:author | pubmed-author:BaxterDD | lld:pubmed |
| pubmed-article:2990708 | pubmed:author | pubmed-author:O'DonnellM... | lld:pubmed |
| pubmed-article:2990708 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2990708 | pubmed:volume | 69 | lld:pubmed |
| pubmed-article:2990708 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2990708 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2990708 | pubmed:pagination | 571-5 | lld:pubmed |
| pubmed-article:2990708 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:2990708 | pubmed:meshHeading | pubmed-meshheading:2990708-... | lld:pubmed |
| pubmed-article:2990708 | pubmed:meshHeading | pubmed-meshheading:2990708-... | lld:pubmed |
| pubmed-article:2990708 | pubmed:meshHeading | pubmed-meshheading:2990708-... | lld:pubmed |
| pubmed-article:2990708 | pubmed:meshHeading | pubmed-meshheading:2990708-... | lld:pubmed |
| pubmed-article:2990708 | pubmed:meshHeading | pubmed-meshheading:2990708-... | lld:pubmed |
| pubmed-article:2990708 | pubmed:meshHeading | pubmed-meshheading:2990708-... | lld:pubmed |
| pubmed-article:2990708 | pubmed:meshHeading | pubmed-meshheading:2990708-... | lld:pubmed |
| pubmed-article:2990708 | pubmed:meshHeading | pubmed-meshheading:2990708-... | lld:pubmed |
| pubmed-article:2990708 | pubmed:meshHeading | pubmed-meshheading:2990708-... | lld:pubmed |
| pubmed-article:2990708 | pubmed:meshHeading | pubmed-meshheading:2990708-... | lld:pubmed |
| pubmed-article:2990708 | pubmed:meshHeading | pubmed-meshheading:2990708-... | lld:pubmed |
| pubmed-article:2990708 | pubmed:meshHeading | pubmed-meshheading:2990708-... | lld:pubmed |
| pubmed-article:2990708 | pubmed:meshHeading | pubmed-meshheading:2990708-... | lld:pubmed |
| pubmed-article:2990708 | pubmed:meshHeading | pubmed-meshheading:2990708-... | lld:pubmed |
| pubmed-article:2990708 | pubmed:meshHeading | pubmed-meshheading:2990708-... | lld:pubmed |
| pubmed-article:2990708 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:2990708 | pubmed:articleTitle | Intensive induction chemotherapy for small cell anaplastic carcinoma of the lung. | lld:pubmed |
| pubmed-article:2990708 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2990708 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:2990708 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2990708 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:2990708 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
