| pubmed-article:2985044 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2985044 | lifeskim:mentions | umls-concept:C0025255 | lld:lifeskim |
| pubmed-article:2985044 | lifeskim:mentions | umls-concept:C1882687 | lld:lifeskim |
| pubmed-article:2985044 | lifeskim:mentions | umls-concept:C0000530 | lld:lifeskim |
| pubmed-article:2985044 | lifeskim:mentions | umls-concept:C0001413 | lld:lifeskim |
| pubmed-article:2985044 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:2985044 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:2985044 | lifeskim:mentions | umls-concept:C0600686 | lld:lifeskim |
| pubmed-article:2985044 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2985044 | pubmed:dateCreated | 1985-5-23 | lld:pubmed |
| pubmed-article:2985044 | pubmed:abstractText | ADP and ATP and their analogues were evaluated as inhibitors of 5'-nucleotidase purified from heart plasma membrane. ADP analogues are more powerful inhibitors than the corresponding ATP analogues. The most powerful inhibitor found is adenosine 5'-[alpha beta-methylene]diphosphate (AOPCP) for which the enzyme shows a Ki of 5 nM at pH 7.2. Measurements of pKi values for ADP and AOPCP as a function of pH indicate that the major inhibitory species of both nucleotides is the dianion. In the physiological range of pH values, AOPCP is a more powerful inhibitor than ADP principally because a higher percentage of AOPCP exists in the dianion form. The methylenephosphonate analogue of AMP (ACP), though not a substrate, is a moderately effective inhibitor. The corresponding analogues of ADP (ACPOP) and ATP (ACPOPOP) are as good inhibitors as ADP and ATP respectively. The thiophosphate analogues of ADP all inhibit 5'-nucleotidase, although not as powerfully as ADP, the most effective of these analogues being adenosine 5'-O-(1-thiodiphosphate) diastereoisomer B (ADP[alpha S](B)]. Other nucleotides inhibit the enzyme, but none is as effective as AOPCP. Inorganic tripolyphosphate and methylenediphosphonate are better inhibitors of the enzyme than is inorganic pyrophosphate. Inorganic thiophosphate is a better inhibitor than is orthophosphate. Hill plots of the ADP and AOPCP inhibition yield slopes close to 1; Hill plots of the ATP inhibition yield slopes of about 0.6. MgADP- is not an inhibitor, and MgATP2- is at best a very weak inhibitor of the enzyme. | lld:pubmed |
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| pubmed-article:2985044 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2985044 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2985044 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2985044 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:2985044 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:2985044 | pubmed:author | pubmed-author:LowensteinJ... | lld:pubmed |
| pubmed-article:2985044 | pubmed:author | pubmed-author:NaitoYY | lld:pubmed |
| pubmed-article:2985044 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2985044 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:2985044 | pubmed:volume | 226 | lld:pubmed |
| pubmed-article:2985044 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2985044 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2985044 | pubmed:pagination | 645-51 | lld:pubmed |
| pubmed-article:2985044 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2985044 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:2985044 | pubmed:articleTitle | 5'-Nucleotidase from rat heart membranes. Inhibition by adenine nucleotides and related compounds. | lld:pubmed |
| pubmed-article:2985044 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2985044 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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